pfp protein (Legionella drancourtii) - STRING interaction network

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pfp

6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (411 aa)

Predicted Functional Partners:

LDG_6049

0.963

LDG_8557

0.939

LDG_6442

0.914

LDG_6443

0.914

LDG_6444

0.914

eno

0.910

LDG_6046

0.908

tpiA

0.899

LDG_8745

0.882

pgk

0.810

Your Current Organism:

Legionella drancourtii

NCBI taxonomy Id: 658187
Other names: L. drancourtii LLAP12, Legionella drancourtii LLAP12, Legionella drancourtii str. LLAP12, Legionella drancourtii strain LLAP12

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LDG_6046	LDG_6049	LDG_6046	LDG_6049	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.994
LDG_6046	LDG_6442	LDG_6046	LDG_6442	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.813
LDG_6046	LDG_6443	LDG_6046	LDG_6443	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Hypothetical protein.	0.813
LDG_6046	LDG_6444	LDG_6046	LDG_6444	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Hypothetical protein.	0.813
LDG_6046	LDG_8557	LDG_6046	LDG_8557	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Hypothetical protein.	0.900
LDG_6046	eno	LDG_6046	LDG_5114	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.986
LDG_6046	pfp	LDG_6046	LDG_7643	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.908
LDG_6046	pgk	LDG_6046	LDG_6048	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.988
LDG_6046	tpiA	LDG_6046	LDG_8777	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Triosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.981
LDG_6049	LDG_6046	LDG_6049	LDG_6046	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.994
LDG_6049	LDG_6442	LDG_6049	LDG_6442	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.926
LDG_6049	LDG_6443	LDG_6049	LDG_6443	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Hypothetical protein.	0.926
LDG_6049	LDG_6444	LDG_6049	LDG_6444	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Hypothetical protein.	0.926
LDG_6049	LDG_8557	LDG_6049	LDG_8557	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Hypothetical protein.	0.896
LDG_6049	eno	LDG_6049	LDG_5114	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.	0.995
LDG_6049	pfp	LDG_6049	LDG_7643	Pyruvate kinase II; Belongs to the pyruvate kinase family.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.963
LDG_6049	pgk	LDG_6049	LDG_6048	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.992
LDG_6049	tpiA	LDG_6049	LDG_8777	Pyruvate kinase II; Belongs to the pyruvate kinase family.	Triosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.	0.959
LDG_6442	LDG_6046	LDG_6442	LDG_6046	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.813
LDG_6442	LDG_6049	LDG_6442	LDG_6049	Glucose-6-phosphate isomerase; Belongs to the GPI family.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.926

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