STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C1645_797602DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (536 aa)    
Predicted Functional Partners:
C1645_756355
Ubiquitin-related domain-containing protein.
    
 0.619
C1645_725595
Small ubiquitin-related modifier-like protein.
    
 0.586
C1645_828577
SP-RING-type domain-containing protein.
    
 0.562
C1645_795963
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.550
C1645_734775
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.524
C1645_760556
DNA topoisomerase.
  
     0.520
C1645_779504
Putative ubiquitin--protein ligase hus5; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.514
C1645_824276
Ubiquitin-conjugating enzyme/RWD-like protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.514
C1645_741810
DNA topoisomerase.
  
     0.508
C1645_786491
Peptidase family C50-domain-containing protein.
   
 
 0.445
Your Current Organism:
Glomus cerebriforme
NCBI taxonomy Id: 658196
Other names: ADW 16899, G. cerebriforme
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.