Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
C1645_770072DNA gyrase/topoisomerase IV, subunit A-domain-containing protein. (95 aa)    
Predicted Functional Partners:
C1645_756355
Ubiquitin-related domain-containing protein.
    
 0.592
C1645_725595
Small ubiquitin-related modifier-like protein.
    
 0.572
C1645_828577
SP-RING-type domain-containing protein.
    
 0.564
C1645_795963
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.541
C1645_701108
Pseudouridine synthase.
  
 
 0.516
C1645_176486
Ubiquitin-conjugating enzyme 19, E2; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.504
C1645_779504
Putative ubiquitin--protein ligase hus5; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.502
C1645_824276
Ubiquitin-conjugating enzyme/RWD-like protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.502
C1645_730751
FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]
   
 
 0.483
C1645_734775
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.476
Your Current Organism:
Glomus cerebriforme
NCBI taxonomy Id: 658196
Other names: ADW 16899, G. cerebriforme
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