node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GMDG_00833 | GMDG_01588 | L8GE36 | L8FVV0 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | AA_TRNA_LIGASE_II domain-containing protein. | 0.491 |
GMDG_00833 | GMDG_02556 | L8GE36 | L8G617 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | 0.445 |
GMDG_00833 | GMDG_03240 | L8GE36 | L8G928 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PEK/GCN2 protein kinase. | 0.487 |
GMDG_01394 | GMDG_02556 | L8FT11 | L8G617 | Actin cytoskeleton-regulatory complex protein end3. | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | 0.544 |
GMDG_01394 | GMDG_05677 | L8FT11 | L8FSP8 | Actin cytoskeleton-regulatory complex protein end3. | Uncharacterized protein. | 0.928 |
GMDG_01588 | GMDG_00833 | L8FVV0 | L8GE36 | AA_TRNA_LIGASE_II domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.491 |
GMDG_01588 | GMDG_02556 | L8FVV0 | L8G617 | AA_TRNA_LIGASE_II domain-containing protein. | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | 0.636 |
GMDG_01588 | GMDG_03240 | L8FVV0 | L8G928 | AA_TRNA_LIGASE_II domain-containing protein. | PEK/GCN2 protein kinase. | 0.860 |
GMDG_01695 | GMDG_02556 | L8FWI9 | L8G617 | Uncharacterized protein. | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | 0.544 |
GMDG_02556 | GMDG_00833 | L8G617 | L8GE36 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.445 |
GMDG_02556 | GMDG_01394 | L8G617 | L8FT11 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | Actin cytoskeleton-regulatory complex protein end3. | 0.544 |
GMDG_02556 | GMDG_01588 | L8G617 | L8FVV0 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | AA_TRNA_LIGASE_II domain-containing protein. | 0.636 |
GMDG_02556 | GMDG_01695 | L8G617 | L8FWI9 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | Uncharacterized protein. | 0.544 |
GMDG_02556 | GMDG_02560 | L8G617 | L8G2C9 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. | 0.469 |
GMDG_02556 | GMDG_03240 | L8G617 | L8G928 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | PEK/GCN2 protein kinase. | 0.474 |
GMDG_02556 | GMDG_04392 | L8G617 | L8GCW1 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | SAM-dependent MTase TRM10-type domain-containing protein. | 0.450 |
GMDG_02556 | GMDG_05379 | L8G617 | L8FN19 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | EH domain-containing protein. | 0.544 |
GMDG_02556 | GMDG_05677 | L8G617 | L8FSP8 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | Uncharacterized protein. | 0.627 |
GMDG_02556 | GMDG_07270 | L8G617 | L8FWL3 | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | Uncharacterized protein. | 0.544 |
GMDG_02560 | GMDG_02556 | L8G2C9 | L8G617 | COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. | 0.469 |