STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GMDG_03525Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (328 aa)    
Predicted Functional Partners:
GMDG_03072
NMT1 domain-containing protein.
  
  
 0.813
GMDG_02132
Uncharacterized protein.
  
  
 0.744
GMDG_05280
Uncharacterized protein.
  
  
 0.700
GMDG_02133
Uncharacterized protein.
  
  
 0.700
GMDG_03549
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
     
 0.631
GMDG_00785
PfkB domain-containing protein.
     
 0.631
GMDG_08994
PfkB domain-containing protein.
     
 0.625
GMDG_08364
Riboflavin biosynthesis protein RibD domain-containing protein.
     
 0.622
GMDG_03285
PfkB domain-containing protein.
     
 0.614
GMDG_02258
TMP-TENI domain-containing protein.
   
  
 0.526
Your Current Organism:
Pseudogymnoascus destructans
NCBI taxonomy Id: 658429
Other names: Geomyces destructans 20631-21, P. destructans 20631-21, Pseudogymnoascus destructans 20631-21
Server load: low (28%) [HD]