EGC75350.1 protein (Lachnospiraceae bacterium 6137FAA)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Knowledge-based Evidence

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Lachnospiraceae bacterium 6137FAA

NCBI taxonomy Id: 658656
Other names: L. bacterium 6_1_37FAA, Lachnospiraceae bacterium 6_1_37FAA

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGC73830.1	EGC75350.1	HMPREF0490_02337	HMPREF0490_00967	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Hypothetical protein.	0.886
EGC73830.1	guaA	HMPREF0490_02337	HMPREF0490_02080	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.787
EGC75350.1	EGC73830.1	HMPREF0490_00967	HMPREF0490_02337	Hypothetical protein.	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.886
EGC75350.1	guaA	HMPREF0490_00967	HMPREF0490_02080	Hypothetical protein.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.928
EGC75350.1	guaB	HMPREF0490_00967	HMPREF0490_01497	Hypothetical protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.902
EGC75350.1	rplF	HMPREF0490_00967	HMPREF0490_02237	Hypothetical protein.	50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.	0.819
EGC75350.1	rplO	HMPREF0490_00967	HMPREF0490_02233	Hypothetical protein.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.819
EGC75350.1	rpsC	HMPREF0490_00967	HMPREF0490_02246	Hypothetical protein.	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.	0.823
EGC75350.1	rpsG	HMPREF0490_00967	HMPREF0490_01946	Hypothetical protein.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.843
EGC75350.1	rpsH	HMPREF0490_00967	HMPREF0490_02238	Hypothetical protein.	30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.	0.824
EGC75350.1	rpsM	HMPREF0490_00967	HMPREF0490_02227	Hypothetical protein.	30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.	0.816
EGC75350.1	rpsQ	HMPREF0490_00967	HMPREF0490_02243	Hypothetical protein.	30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	0.822
guaA	EGC73830.1	HMPREF0490_02080	HMPREF0490_02337	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.787
guaA	EGC75350.1	HMPREF0490_02080	HMPREF0490_00967	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Hypothetical protein.	0.928
guaA	guaB	HMPREF0490_02080	HMPREF0490_01497	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	rplF	HMPREF0490_02080	HMPREF0490_02237	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.	0.486
guaA	rplO	HMPREF0490_02080	HMPREF0490_02233	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.539
guaA	rpsC	HMPREF0490_02080	HMPREF0490_02246	GMP synthase; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.	0.868
guaA	rpsG	HMPREF0490_02080	HMPREF0490_01946	GMP synthase; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.	0.820
guaA	rpsH	HMPREF0490_02080	HMPREF0490_02238	GMP synthase; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.	0.643