| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGC73702.1 | EGC73909.1 | HMPREF0490_02723 | HMPREF0490_02416 | Hypothetical protein. | Ribose 5-phosphate isomerase B. | 0.851 |
| EGC73702.1 | EGC75255.1 | HMPREF0490_02723 | HMPREF0490_01145 | Hypothetical protein. | Phosphoribosylformylglycinamidine synthase. | 0.999 |
| EGC73702.1 | EGC75400.1 | HMPREF0490_02723 | HMPREF0490_01017 | Hypothetical protein. | Hypothetical protein. | 0.891 |
| EGC73702.1 | fhs | HMPREF0490_02723 | HMPREF0490_00841 | Hypothetical protein. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.977 |
| EGC73702.1 | folD | HMPREF0490_02723 | HMPREF0490_00824 | Hypothetical protein. | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.902 |
| EGC73702.1 | folD-2 | HMPREF0490_02723 | HMPREF0490_00842 | Hypothetical protein. | folD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.902 |
| EGC73702.1 | glyA | HMPREF0490_02723 | HMPREF0490_00992 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| EGC73702.1 | purN | HMPREF0490_02723 | HMPREF0490_02614 | Hypothetical protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| EGC73909.1 | EGC73702.1 | HMPREF0490_02416 | HMPREF0490_02723 | Ribose 5-phosphate isomerase B. | Hypothetical protein. | 0.851 |
| EGC73909.1 | EGC74454.1 | HMPREF0490_02416 | HMPREF0490_01876 | Ribose 5-phosphate isomerase B. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.422 |
| EGC73909.1 | EGC74455.1 | HMPREF0490_02416 | HMPREF0490_01877 | Ribose 5-phosphate isomerase B. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.422 |
| EGC73909.1 | EGC75255.1 | HMPREF0490_02416 | HMPREF0490_01145 | Ribose 5-phosphate isomerase B. | Phosphoribosylformylglycinamidine synthase. | 0.436 |
| EGC73909.1 | EGC75400.1 | HMPREF0490_02416 | HMPREF0490_01017 | Ribose 5-phosphate isomerase B. | Hypothetical protein. | 0.895 |
| EGC73909.1 | fhs | HMPREF0490_02416 | HMPREF0490_00841 | Ribose 5-phosphate isomerase B. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.841 |
| EGC73909.1 | folD | HMPREF0490_02416 | HMPREF0490_00824 | Ribose 5-phosphate isomerase B. | Hypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.843 |
| EGC73909.1 | folD-2 | HMPREF0490_02416 | HMPREF0490_00842 | Ribose 5-phosphate isomerase B. | folD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.843 |
| EGC73909.1 | glyA | HMPREF0490_02416 | HMPREF0490_00992 | Ribose 5-phosphate isomerase B. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
| EGC73909.1 | purN | HMPREF0490_02416 | HMPREF0490_02614 | Ribose 5-phosphate isomerase B. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.821 |
| EGC74454.1 | EGC73909.1 | HMPREF0490_01876 | HMPREF0490_02416 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Ribose 5-phosphate isomerase B. | 0.422 |
| EGC74454.1 | EGC74455.1 | HMPREF0490_01876 | HMPREF0490_01877 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.999 |
