| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGC74142.1 | EGC74756.1 | HMPREF0490_02170 | HMPREF0490_01636 | Hypothetical protein. | Glutamine synthetase. | 0.608 |
| EGC74142.1 | EGC75254.1 | HMPREF0490_02170 | HMPREF0490_01144 | Hypothetical protein. | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.894 |
| EGC74142.1 | EGC75255.1 | HMPREF0490_02170 | HMPREF0490_01145 | Hypothetical protein. | Phosphoribosylformylglycinamidine synthase. | 0.430 |
| EGC74142.1 | EGC75416.1 | HMPREF0490_02170 | HMPREF0490_00846 | Hypothetical protein. | Glutamate synthase. | 0.879 |
| EGC74142.1 | EGC75732.1 | HMPREF0490_02170 | HMPREF0490_00373 | Hypothetical protein. | Hypothetical protein. | 0.655 |
| EGC74142.1 | murI | HMPREF0490_02170 | HMPREF0490_02307 | Hypothetical protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.886 |
| EGC74295.1 | EGC74756.1 | HMPREF0490_01912 | HMPREF0490_01636 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamine synthetase. | 0.616 |
| EGC74295.1 | EGC75254.1 | HMPREF0490_01912 | HMPREF0490_01144 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.501 |
| EGC74295.1 | EGC75255.1 | HMPREF0490_01912 | HMPREF0490_01145 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylformylglycinamidine synthase. | 0.677 |
| EGC74295.1 | guaA | HMPREF0490_01912 | HMPREF0490_02080 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.963 |
| EGC74295.1 | murD | HMPREF0490_01912 | HMPREF0490_01702 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.563 |
| EGC74295.1 | murI | HMPREF0490_01912 | HMPREF0490_02307 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.912 |
| EGC74298.1 | EGC74756.1 | HMPREF0490_01915 | HMPREF0490_01636 | Hypothetical protein; Belongs to the glutamine synthetase family. | Glutamine synthetase. | 0.898 |
| EGC74298.1 | EGC75254.1 | HMPREF0490_01915 | HMPREF0490_01144 | Hypothetical protein; Belongs to the glutamine synthetase family. | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.908 |
| EGC74298.1 | EGC75255.1 | HMPREF0490_01915 | HMPREF0490_01145 | Hypothetical protein; Belongs to the glutamine synthetase family. | Phosphoribosylformylglycinamidine synthase. | 0.570 |
| EGC74298.1 | EGC75416.1 | HMPREF0490_01915 | HMPREF0490_00846 | Hypothetical protein; Belongs to the glutamine synthetase family. | Glutamate synthase. | 0.880 |
| EGC74298.1 | EGC75732.1 | HMPREF0490_01915 | HMPREF0490_00373 | Hypothetical protein; Belongs to the glutamine synthetase family. | Hypothetical protein. | 0.773 |
| EGC74298.1 | murI | HMPREF0490_01915 | HMPREF0490_02307 | Hypothetical protein; Belongs to the glutamine synthetase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.875 |
| EGC74756.1 | EGC74142.1 | HMPREF0490_01636 | HMPREF0490_02170 | Glutamine synthetase. | Hypothetical protein. | 0.608 |
| EGC74756.1 | EGC74295.1 | HMPREF0490_01636 | HMPREF0490_01912 | Glutamine synthetase. | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.616 |
