Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFP61396.1Amidohydrolase family protein. (527 aa)    
Predicted Functional Partners:
EFP61395.1
Transporter, major facilitator family protein.
     
 0.797
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
  0.761
parC
DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
    
  0.761
EFP59710.1
Phosphogluconate dehydrogenase (decarboxylating), NAD binding domain protein.
    
  0.701
EFP62277.1
4Fe-4S binding domain protein.
    
  0.669
EFP62014.1
4Fe-4S binding domain protein.
    
  0.669
EFP61707.1
4Fe-4S binding domain protein.
    
  0.669
EFP60165.1
Hydrolase, NUDIX family.
    
  0.655
EFP61393.1
Hypothetical protein.
       0.558
EFP61394.1
HTH domain protein.
       0.558
Your Current Organism:
Erysipelotrichaceae bacterium 3153
NCBI taxonomy Id: 658659
Other names: E. bacterium 3_1_53, Erysipelotrichaceae bacterium 3_1_53, Erysipelotrichaceae bacterium str. 3_1_53, Erysipelotrichaceae bacterium strain 3_1_53
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