node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KMZ53175.1 | KMZ54727.1 | HMPREF0980_02738 | HMPREF0980_01139 | Iron-sulfur cluster-binding protein, Rieske family. | Vitamin B12-dependent methionine synthase family protein. | 0.851 |
KMZ53175.1 | KMZ55218.1 | HMPREF0980_02738 | HMPREF0980_00566 | Iron-sulfur cluster-binding protein, Rieske family. | SAM dependent methyltransferase. | 0.623 |
KMZ53175.1 | glyA | HMPREF0980_02738 | HMPREF0980_00496 | Iron-sulfur cluster-binding protein, Rieske family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.710 |
KMZ53175.1 | nadE | HMPREF0980_02738 | HMPREF0980_00568 | Iron-sulfur cluster-binding protein, Rieske family. | Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.705 |
KMZ53837.1 | KMZ55218.1 | HMPREF0980_02064 | HMPREF0980_00566 | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | SAM dependent methyltransferase. | 0.517 |
KMZ53837.1 | glyA | HMPREF0980_02064 | HMPREF0980_00496 | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.425 |
KMZ53837.1 | nadE | HMPREF0980_02064 | HMPREF0980_00568 | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.618 |
KMZ54727.1 | KMZ53175.1 | HMPREF0980_01139 | HMPREF0980_02738 | Vitamin B12-dependent methionine synthase family protein. | Iron-sulfur cluster-binding protein, Rieske family. | 0.851 |
KMZ54727.1 | KMZ55218.1 | HMPREF0980_01139 | HMPREF0980_00566 | Vitamin B12-dependent methionine synthase family protein. | SAM dependent methyltransferase. | 0.523 |
KMZ54727.1 | KMZ55221.1 | HMPREF0980_01139 | HMPREF0980_00569 | Vitamin B12-dependent methionine synthase family protein. | Putative redox family protein. | 0.792 |
KMZ54727.1 | glyA | HMPREF0980_01139 | HMPREF0980_00496 | Vitamin B12-dependent methionine synthase family protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
KMZ54727.1 | nadE | HMPREF0980_01139 | HMPREF0980_00568 | Vitamin B12-dependent methionine synthase family protein. | Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.439 |
KMZ54727.1 | prmA | HMPREF0980_01139 | HMPREF0980_00447 | Vitamin B12-dependent methionine synthase family protein. | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.420 |
KMZ55218.1 | KMZ53175.1 | HMPREF0980_00566 | HMPREF0980_02738 | SAM dependent methyltransferase. | Iron-sulfur cluster-binding protein, Rieske family. | 0.623 |
KMZ55218.1 | KMZ53837.1 | HMPREF0980_00566 | HMPREF0980_02064 | SAM dependent methyltransferase. | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. | 0.517 |
KMZ55218.1 | KMZ54727.1 | HMPREF0980_00566 | HMPREF0980_01139 | SAM dependent methyltransferase. | Vitamin B12-dependent methionine synthase family protein. | 0.523 |
KMZ55218.1 | KMZ55221.1 | HMPREF0980_00566 | HMPREF0980_00569 | SAM dependent methyltransferase. | Putative redox family protein. | 0.606 |
KMZ55218.1 | KMZ55563.1 | HMPREF0980_00566 | HMPREF0980_00261 | SAM dependent methyltransferase. | Putative ABC1 domain protein. | 0.527 |
KMZ55218.1 | glyA | HMPREF0980_00566 | HMPREF0980_00496 | SAM dependent methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.612 |
KMZ55218.1 | hslO | HMPREF0980_00566 | HMPREF0980_00567 | SAM dependent methyltransferase. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.856 |