node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDD59950.1 | SDE52685.1 | SAMN04487996_101410 | SAMN04487996_105284 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | 2-oxoglutarate dehydrogenase E1 component. | 0.997 |
SDD59950.1 | SDE67025.1 | SAMN04487996_101410 | SAMN04487996_106165 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | 0.999 |
SDD59950.1 | SDF97325.1 | SAMN04487996_101410 | SAMN04487996_11437 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Dihydrolipoamide dehydrogenase. | 0.729 |
SDD59950.1 | gcvH | SAMN04487996_101410 | SAMN04487996_109289 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.969 |
SDD59950.1 | gcvP | SAMN04487996_101410 | SAMN04487996_11863 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.901 |
SDD59950.1 | gcvT | SAMN04487996_101410 | SAMN04487996_12937 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
SDD59950.1 | glyA | SAMN04487996_101410 | SAMN04487996_114219 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.733 |
SDD59950.1 | lipA | SAMN04487996_101410 | SAMN04487996_12466 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.517 |
SDE52685.1 | SDD59950.1 | SAMN04487996_105284 | SAMN04487996_101410 | 2-oxoglutarate dehydrogenase E1 component. | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | 0.997 |
SDE52685.1 | SDE67025.1 | SAMN04487996_105284 | SAMN04487996_106165 | 2-oxoglutarate dehydrogenase E1 component. | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | 0.999 |
SDE52685.1 | SDF97325.1 | SAMN04487996_105284 | SAMN04487996_11437 | 2-oxoglutarate dehydrogenase E1 component. | Dihydrolipoamide dehydrogenase. | 0.998 |
SDE52685.1 | SDG22924.1 | SAMN04487996_105284 | SAMN04487996_116120 | 2-oxoglutarate dehydrogenase E1 component. | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | 0.997 |
SDE52685.1 | gcvH | SAMN04487996_105284 | SAMN04487996_109289 | 2-oxoglutarate dehydrogenase E1 component. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.981 |
SDE52685.1 | gcvP | SAMN04487996_105284 | SAMN04487996_11863 | 2-oxoglutarate dehydrogenase E1 component. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.908 |
SDE52685.1 | gcvT | SAMN04487996_105284 | SAMN04487996_12937 | 2-oxoglutarate dehydrogenase E1 component. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.824 |
SDE52685.1 | glyA | SAMN04487996_105284 | SAMN04487996_114219 | 2-oxoglutarate dehydrogenase E1 component. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.584 |
SDE67025.1 | SDD59950.1 | SAMN04487996_106165 | SAMN04487996_101410 | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | 0.999 |
SDE67025.1 | SDE52685.1 | SAMN04487996_106165 | SAMN04487996_105284 | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | 2-oxoglutarate dehydrogenase E1 component. | 0.999 |
SDE67025.1 | SDF97325.1 | SAMN04487996_106165 | SAMN04487996_11437 | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | Dihydrolipoamide dehydrogenase. | 0.999 |
SDE67025.1 | SDG22924.1 | SAMN04487996_106165 | SAMN04487996_116120 | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. | 0.999 |