STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (157 aa)    
Predicted Functional Partners:
AFK07292.1
DNA-directed RNA polymerase, beta subunit/140 kD subunit; PFAM: RNA polymerase Rpb1, domain 2; RNA polymerase Rpb2, domain 6; RNA polymerase Rpb1, domain 5.
  
 
 0.966
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.909
AFK06447.1
DNA-directed RNA polymerase, subunit K/omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
   
 
 0.895
rpoC
DNA-directed RNA polymerase, beta' subunit/160 kD subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.884
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
   
   0.801
nrdR
Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
     
 0.795
AFK05778.1
PFAM: Yqey-like protein.
  
    0.779
lysS
lysyl-tRNA synthetase (class II); PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.770
whiA
Hypothetical protein; Involved in cell division and chromosome segregation.
       0.758
AFK05779.1
Hypothetical protein; PFAM: Hydantoinase/oxoprolinase; TIGRFAM: conserved hypothetical protein.
  
    0.754
Your Current Organism:
Mesotoga prima
NCBI taxonomy Id: 660470
Other names: M. prima MesG1.Ag.4.2, Mesotoga prima MesG1.Ag.4.2, Thermotogales bacterium MesG1.Ag.4.2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.