Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFK06461.1Hypothetical protein. (154 aa)    
Predicted Functional Partners:
AFK05824.1
TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
  
 0.868
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.847
AFK06462.1
Hypothetical protein; PFAM: Dinitrogenase iron-molybdenum cofactor.
       0.565
AFK06463.1
P-loop ATPase, MinD superfamily; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; 4Fe-4S binding domain.
       0.565
AFK06464.1
P-loop ATPase, MinD superfamily; PFAM: 4Fe-4S binding domain; CobQ/CobB/MinD/ParA nucleotide binding domain.
       0.565
AFK06465.1
Hypothetical protein.
       0.565
AFK06466.1
Hypothetical protein.
       0.565
AFK06428.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.521
AFK07230.1
Hypothetical protein.
    
 0.521
AFK06064.1
Lipid A core-O-antigen ligase-like enyme; PFAM: O-Antigen ligase.
  
     0.437
Your Current Organism:
Mesotoga prima
NCBI taxonomy Id: 660470
Other names: M. prima MesG1.Ag.4.2, Mesotoga prima MesG1.Ag.4.2, Thermotogales bacterium MesG1.Ag.4.2
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