AFK06491.1 protein (Mesotoga prima) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

AFK06491.1

PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. (185 aa)

Predicted Functional Partners:

AFK06365.1

0.973

AFK06428.1

0.964

dnaX

0.949

AFK07023.1

0.949

AFK06388.1

0.946

AFK06474.1

0.929

polC

0.919

AFK06492.1

0.818

AFK06495.1

0.810

AFK06493.1

0.774

Your Current Organism:

Mesotoga prima

NCBI taxonomy Id: 660470
Other names: M. prima MesG1.Ag.4.2, Mesotoga prima MesG1.Ag.4.2, Thermotogales bacterium MesG1.Ag.4.2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFK06365.1	AFK06388.1	Theba_0648	Theba_0671	PFAM: Bacterial DNA polymerase III alpha subunit.	DNA polymerase III, delta subunit.	0.987
AFK06365.1	AFK06428.1	Theba_0648	Theba_0711	PFAM: Bacterial DNA polymerase III alpha subunit.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.989
AFK06365.1	AFK06474.1	Theba_0648	Theba_0759	PFAM: Bacterial DNA polymerase III alpha subunit.	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.928
AFK06365.1	AFK06491.1	Theba_0648	Theba_0777	PFAM: Bacterial DNA polymerase III alpha subunit.	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.973
AFK06365.1	AFK07023.1	Theba_0648	Theba_1335	PFAM: Bacterial DNA polymerase III alpha subunit.	Hypothetical protein.	0.976
AFK06365.1	dnaX	Theba_0648	Theba_0011	PFAM: Bacterial DNA polymerase III alpha subunit.	DNA polymerase III, subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.982
AFK06365.1	polC	Theba_0648	Theba_1557	PFAM: Bacterial DNA polymerase III alpha subunit.	DNA polymerase III, alpha chain; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.929
AFK06388.1	AFK06365.1	Theba_0671	Theba_0648	DNA polymerase III, delta subunit.	PFAM: Bacterial DNA polymerase III alpha subunit.	0.987
AFK06388.1	AFK06428.1	Theba_0671	Theba_0711	DNA polymerase III, delta subunit.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.986
AFK06388.1	AFK06474.1	Theba_0671	Theba_0759	DNA polymerase III, delta subunit.	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.917
AFK06388.1	AFK06491.1	Theba_0671	Theba_0777	DNA polymerase III, delta subunit.	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.946
AFK06388.1	AFK07023.1	Theba_0671	Theba_1335	DNA polymerase III, delta subunit.	Hypothetical protein.	0.972
AFK06388.1	dnaX	Theba_0671	Theba_0011	DNA polymerase III, delta subunit.	DNA polymerase III, subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.972
AFK06388.1	polC	Theba_0671	Theba_1557	DNA polymerase III, delta subunit.	DNA polymerase III, alpha chain; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.917
AFK06428.1	AFK06365.1	Theba_0711	Theba_0648	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	PFAM: Bacterial DNA polymerase III alpha subunit.	0.989
AFK06428.1	AFK06388.1	Theba_0711	Theba_0671	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III, delta subunit.	0.986
AFK06428.1	AFK06474.1	Theba_0711	Theba_0759	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.918
AFK06428.1	AFK06491.1	Theba_0711	Theba_0777	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.	0.964
AFK06428.1	AFK07023.1	Theba_0711	Theba_1335	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Hypothetical protein.	0.970
AFK06428.1	dnaX	Theba_0711	Theba_0011	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	DNA polymerase III, subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.970