Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFK06520.1Membrane protease subunit, stomatin/prohibitin; HflC and HflK could regulate a protease. (285 aa)    
Predicted Functional Partners:
AFK06519.1
HflK protein; HflC and HflK could encode or regulate a protease.
 
     0.957
AFK06517.1
Hypothetical protein.
  
    0.827
AFK06521.1
PFAM: Uncharacterized protein family UPF0029; TIGRFAM: uncharacterized protein, YigZ family.
       0.798
murB
UDP-N-acetylmuramate dehydrogenase; Cell wall formation.
       0.784
AFK06516.1
ATPase involved in DNA repair; May be involved in recombinational repair of damaged DNA.
       0.764
AFK06661.1
Membrane protein implicated in regulation of membrane protease activity; PFAM: NfeD-like.
 
 
 0.740
yidC
Membrane protein insertase, YidC/Oxa1 family, C-terminal domain protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
  
 
 0.712
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 0.689
AFK05933.1
Putative Zn-dependent peptidase; PFAM: Peptidase M16 inactive domain; Insulinase (Peptidase family M16); Belongs to the peptidase M16 family.
  
 0.584
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
     
 0.502
Your Current Organism:
Mesotoga prima
NCBI taxonomy Id: 660470
Other names: M. prima MesG1.Ag.4.2, Mesotoga prima MesG1.Ag.4.2, Thermotogales bacterium MesG1.Ag.4.2
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