node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDE91987.1 | SDF84008.1 | SAMN05216218_102198 | SAMN05216218_11066 | Replicative DNA helicase Mcm. | Intein C-terminal splicing region/intein N-terminal splicing region. | 0.990 |
SDE91987.1 | SDG02445.1 | SAMN05216218_102198 | SAMN05216218_113111 | Replicative DNA helicase Mcm. | Replication factor A1. | 0.942 |
SDE91987.1 | fen | SAMN05216218_102198 | SAMN05216218_101236 | Replicative DNA helicase Mcm. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.746 |
SDE91987.1 | pcn | SAMN05216218_102198 | SAMN05216218_102258 | Replicative DNA helicase Mcm. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.955 |
SDE91987.1 | polB | SAMN05216218_102198 | SAMN05216218_10528 | Replicative DNA helicase Mcm. | DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.613 |
SDE91987.1 | priL | SAMN05216218_102198 | SAMN05216218_102260 | Replicative DNA helicase Mcm. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.988 |
SDE91987.1 | priS | SAMN05216218_102198 | SAMN05216218_10825 | Replicative DNA helicase Mcm. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.980 |
SDE91987.1 | rfcL | SAMN05216218_102198 | SAMN05216218_107113 | Replicative DNA helicase Mcm. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.895 |
SDF84008.1 | SDE91987.1 | SAMN05216218_11066 | SAMN05216218_102198 | Intein C-terminal splicing region/intein N-terminal splicing region. | Replicative DNA helicase Mcm. | 0.990 |
SDF84008.1 | SDG02445.1 | SAMN05216218_11066 | SAMN05216218_113111 | Intein C-terminal splicing region/intein N-terminal splicing region. | Replication factor A1. | 0.594 |
SDF84008.1 | dbh | SAMN05216218_11066 | SAMN05216218_101456 | Intein C-terminal splicing region/intein N-terminal splicing region. | DNA polymerase IV (DinB-like DNA polymerase); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.972 |
SDF84008.1 | fen | SAMN05216218_11066 | SAMN05216218_101236 | Intein C-terminal splicing region/intein N-terminal splicing region. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.952 |
SDF84008.1 | pcn | SAMN05216218_11066 | SAMN05216218_102258 | Intein C-terminal splicing region/intein N-terminal splicing region. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.999 |
SDF84008.1 | polB | SAMN05216218_11066 | SAMN05216218_10528 | Intein C-terminal splicing region/intein N-terminal splicing region. | DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.999 |
SDF84008.1 | priL | SAMN05216218_11066 | SAMN05216218_102260 | Intein C-terminal splicing region/intein N-terminal splicing region. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.994 |
SDF84008.1 | priS | SAMN05216218_11066 | SAMN05216218_10825 | Intein C-terminal splicing region/intein N-terminal splicing region. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.994 |
SDF84008.1 | rfcL | SAMN05216218_11066 | SAMN05216218_107113 | Intein C-terminal splicing region/intein N-terminal splicing region. | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.863 |
SDG02445.1 | SDE91987.1 | SAMN05216218_113111 | SAMN05216218_102198 | Replication factor A1. | Replicative DNA helicase Mcm. | 0.942 |
SDG02445.1 | SDF84008.1 | SAMN05216218_113111 | SAMN05216218_11066 | Replication factor A1. | Intein C-terminal splicing region/intein N-terminal splicing region. | 0.594 |
SDG02445.1 | dbh | SAMN05216218_113111 | SAMN05216218_101456 | Replication factor A1. | DNA polymerase IV (DinB-like DNA polymerase); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.466 |