STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDM81767.12-(3-amino-3-carboxypropyl)histidine synthase; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (348 aa)    
Predicted Functional Partners:
fusA
Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
  
 
 0.997
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
  
 
 0.809
rpl10e
LSU ribosomal protein L10AE; Manually curated; Belongs to the universal ribosomal protein uL16 family.
 
 
   0.755
pcn
Proliferating cell antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
     0.691
prf1
Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
    0.665
SDM06648.1
Translation initiation factor 2 subunit 2.
  
     0.648
eif2b
Translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.
  
     0.641
SDM16736.1
metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein.
  
   
 0.617
rps4e
Small subunit ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family.
  
     0.607
SDM19098.1
Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN metalloenzyme (JAMM) motif.
  
   0.603
Your Current Organism:
Halogranum gelatinilyticum
NCBI taxonomy Id: 660521
Other names: CGMCC 1.10119, H. gelatinilyticum, Halobacteriaceae archaeon TNN44, Halogranum gelatinilyticum Cui et al. 2011, JCM 16426, strain TNN44
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