| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ftsL | ftsZ | DSJ_06210 | DSJ_06270 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.625 |
| ftsL | hemD | DSJ_06210 | DSJ_22105 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.430 |
| ftsL | mreD | DSJ_06210 | DSJ_21750 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.558 |
| ftsL | rodZ | DSJ_06210 | DSJ_07535 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Helix-turn-helix domain-containing protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.641 |
| ftsL | zapA | DSJ_06210 | DSJ_04760 | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.621 |
| ftsZ | ftsL | DSJ_06270 | DSJ_06210 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.625 |
| ftsZ | zapA | DSJ_06270 | DSJ_04760 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.663 |
| hemD | ftsL | DSJ_22105 | DSJ_06210 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.430 |
| hemD | mreD | DSJ_22105 | DSJ_21750 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.449 |
| hemD | zapA | DSJ_22105 | DSJ_04760 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.659 |
| ihfA | zapA | DSJ_12885 | DSJ_04760 | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.687 |
| mreD | ftsL | DSJ_21750 | DSJ_06210 | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.558 |
| mreD | hemD | DSJ_21750 | DSJ_22105 | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.449 |
| mreD | rodZ | DSJ_21750 | DSJ_07535 | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | Helix-turn-helix domain-containing protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | 0.745 |
| mreD | ygfB | DSJ_21750 | DSJ_04765 | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | Hypothetical protein; The crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0149 family. | 0.623 |
| mreD | zapA | DSJ_21750 | DSJ_04760 | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.676 |
| pepP | ubiH | DSJ_04770 | DSJ_04775 | Xaa-Pro aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2-octaprenyl-6-methoxyphenyl hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.832 |
| pepP | ygfB | DSJ_04770 | DSJ_04765 | Xaa-Pro aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; The crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0149 family. | 0.718 |
| pepP | zapA | DSJ_04770 | DSJ_04760 | Xaa-Pro aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Z-ring-associated protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.593 |
| rodZ | ftsL | DSJ_07535 | DSJ_06210 | Helix-turn-helix domain-containing protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.641 |