STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAV25603.1Fis family transcriptional regulator. (511 aa)    
Predicted Functional Partners:
GAV25331.1
DNA processing protein DprA.
 
 0.827
GAV25287.1
Hypothetical protein.
 
  
 0.775
GAV25460.1
DNA internalization-related competence protein ComEC/Rec2.
 
  
 0.662
GAV25894.1
Hypothetical protein; Belongs to the UPF0102 family.
 
  
 0.630
GAV25604.1
Nucleotide-binding protein; Belongs to the UPF0234 family.
       0.620
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.497
GAV24900.1
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
     
 0.479
nnrD
Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...]
       0.455
GAV26165.1
Flagellar basal-body rod protein FlgF.
   
   0.402
GAV26178.1
Hypothetical protein.
   
   0.402
Your Current Organism:
Carboxydothermus islandicus
NCBI taxonomy Id: 661089
Other names: C. islandicus, Carboxydothermus islandicus Novikov et al. 2011, Carboxydothermus sp. SET IS-9, DSM 21830, VKM B-2561, strain SET IS-9
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