AIE84435.1 protein (Fimbriimonas ginsengisoli)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

AIE84435.1

Multi-sensor Signal Transduction Histidine Kinase. (580 aa)

Predicted Functional Partners:

AIE86417.1

0.988

AIE85390.1

0.987

AIE86121.1

0.987

AIE86470.1

0.987

AIE86900.1

0.982

AIE87165.1

0.981

AIE86008.1

0.978

AIE86358.1

0.977

AIE85277.1

0.976

AIE83436.1

0.838

Your Current Organism:

Fimbriimonas ginsengisoli

NCBI taxonomy Id: 661478
Other names: F. ginsengisoli Gsoil 348, Fimbriimonas ginsengisoli Gsoil 348, Fimbriimonas ginsengisoli str. Gsoil 348, Fimbriimonas ginsengisoli strain Gsoil 348, candidate division OP10 bacterium Gsoil 348

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIE83436.1	AIE84435.1	OP10G_0068	OP10G_1067	Response regulator receiver domain-containing protein.	Multi-sensor Signal Transduction Histidine Kinase.	0.838
AIE83436.1	AIE85277.1	OP10G_0068	OP10G_1909	Response regulator receiver domain-containing protein.	Sensory box histidine kinase/response regulator.	0.471
AIE83436.1	AIE86008.1	OP10G_0068	OP10G_2640	Response regulator receiver domain-containing protein.	Two-component system sensor protein.	0.457
AIE83436.1	AIE86358.1	OP10G_0068	OP10G_2990	Response regulator receiver domain-containing protein.	Sensory box histidine kinase/response regulator.	0.567
AIE83436.1	AIE86417.1	OP10G_0068	OP10G_3049	Response regulator receiver domain-containing protein.	Response regulator receiver.	0.455
AIE83436.1	AIE86900.1	OP10G_0068	OP10G_3532	Response regulator receiver domain-containing protein.	Putative hybrid histidine kinase.	0.783
AIE83436.1	AIE87165.1	OP10G_0068	OP10G_3797	Response regulator receiver domain-containing protein.	Multi-sensor hybrid histidine kinase.	0.725
AIE84435.1	AIE83436.1	OP10G_1067	OP10G_0068	Multi-sensor Signal Transduction Histidine Kinase.	Response regulator receiver domain-containing protein.	0.838
AIE84435.1	AIE85277.1	OP10G_1067	OP10G_1909	Multi-sensor Signal Transduction Histidine Kinase.	Sensory box histidine kinase/response regulator.	0.976
AIE84435.1	AIE85390.1	OP10G_1067	OP10G_2022	Multi-sensor Signal Transduction Histidine Kinase.	PAS/PAC sensor hybrid histidine kinase.	0.987
AIE84435.1	AIE86008.1	OP10G_1067	OP10G_2640	Multi-sensor Signal Transduction Histidine Kinase.	Two-component system sensor protein.	0.978
AIE84435.1	AIE86121.1	OP10G_1067	OP10G_2753	Multi-sensor Signal Transduction Histidine Kinase.	Sensory box histidine kinase/response regulator.	0.987
AIE84435.1	AIE86358.1	OP10G_1067	OP10G_2990	Multi-sensor Signal Transduction Histidine Kinase.	Sensory box histidine kinase/response regulator.	0.977
AIE84435.1	AIE86417.1	OP10G_1067	OP10G_3049	Multi-sensor Signal Transduction Histidine Kinase.	Response regulator receiver.	0.988
AIE84435.1	AIE86470.1	OP10G_1067	OP10G_3102	Multi-sensor Signal Transduction Histidine Kinase.	Sensory box histidine kinase/response regulator.	0.987
AIE84435.1	AIE86900.1	OP10G_1067	OP10G_3532	Multi-sensor Signal Transduction Histidine Kinase.	Putative hybrid histidine kinase.	0.982
AIE84435.1	AIE87165.1	OP10G_1067	OP10G_3797	Multi-sensor Signal Transduction Histidine Kinase.	Multi-sensor hybrid histidine kinase.	0.981
AIE85277.1	AIE83436.1	OP10G_1909	OP10G_0068	Sensory box histidine kinase/response regulator.	Response regulator receiver domain-containing protein.	0.471
AIE85277.1	AIE84435.1	OP10G_1909	OP10G_1067	Sensory box histidine kinase/response regulator.	Multi-sensor Signal Transduction Histidine Kinase.	0.976
AIE85277.1	AIE85390.1	OP10G_1909	OP10G_2022	Sensory box histidine kinase/response regulator.	PAS/PAC sensor hybrid histidine kinase.	0.632

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.695

expected number of edges:

15

PPI enrichment p-value:

0.234

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051028

mRNA transport

10 of 79

2.7

10.92

3.66e-23

GO:0006406

mRNA export from nucleus

9 of 56

2.8

10.61

8.32e-22

GO:0006397

mRNA processing

6 of 414

1.76

2.83

6.86e-08

GO:0010467

Gene expression

11 of 1776

1.39

2.62

1.99e-13

GO:0016973

poly(A)+ mRNA export from nucleus

2 of 22

2.56

1.44

0.0023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1120

1.59

3.6

6.56e-15

GO:0003729

mRNA binding

5 of 205

1.98

2.92

4.19e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000445

THO complex part of transcription export complex

5 of 8

3.39

6.81

4.04e-13

GO:0016607

Nuclear speck

5 of 143

2.14

3.57

2.85e-08

GO:0140513

Nuclear protein-containing complex

8 of 1136

1.44

2.32

7.61e-09

GO:0005681

Spliceosomal complex

3 of 278

1.63

1.22

0.0023

GO:0005634

Nucleus

11 of 5174

0.92

1.08

1.22e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8411

mRNA export from nucleus, and THO complex subunit 2

9 of 30

3.07

12.05

1.08e-23

CL:8409

mRNA transport, and Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

10 of 66

2.78

11.61

3.37e-24

CL:8419

THO complex, and poly(A)+ mRNA export from nucleus

8 of 19

3.22

11.26

9.85e-22

CL:8408

Mixed, incl. RNA Polymerase II Transcription Termination, and Regulation of RNA splicing

11 of 116

2.57

11.24

3.62e-25

CL:8423

THO complex

5 of 10

3.3

6.67

6.50e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu03040

Spliceosome

6 of 109

2.34

5.17

1.68e-11

aqu03013

RNA transport

6 of 125

2.28

5.05

1.86e-11

aqu03015

mRNA surveillance pathway

2 of 66

2.08

1.19

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73856

RNA Polymerase II Transcription Termination

11 of 97

2.65

12.14

1.31e-26

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

11 of 100

2.64

12.08

1.31e-26

MAP-72202

Transport of Mature Transcript to Cytoplasm

11 of 111

2.59

11.82

1.77e-26

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 476

1.96

6.32

7.74e-20

MAP-8953854

Metabolism of RNA

11 of 1040

1.62

3.9

3.11e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000347

THO complex

5 of 10

3.3

6.52

1.20e-12

GOCC:0000346

Transcription export complex

5 of 11

3.25

6.51

1.20e-12

GOCC:0000445

THO complex part of transcription export complex

3 of 6

3.3

3.71

1.88e-07

GOCC:0016607

Nuclear speck

3 of 29

2.61

2.75

7.38e-06

GOCC:0005634

Nucleus

11 of 2291

1.28

2.15

3.35e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

4 of 246

1.81

1.88

8.76e-05

KW-0508

mRNA splicing

2 of 22

2.56

1.46

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16134

THO complex subunit 2 N-terminus

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR032302

THO complex subunit 2, N-terminal domain

2 of 2

3.6

1.89

0.00040

IPR000504

RNA recognition motif domain

4 of 158

2.0

1.78

0.00028

IPR035979

RNA-binding domain superfamily

4 of 177

1.95

1.75

0.00028

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

4 of 186

1.93

1.74

0.00028

IPR040007

THO complex subunit 2

2 of 6

3.12

1.57

0.0015

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

4 of 151

2.02

2.23

2.68e-05

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