STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaABGMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (305 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 0.997
guaAA
GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP.
  
 0.997
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 0.991
C440_08397
COG0518 GMP synthase - Glutamine amidotransferase domain.
  
 0.979
C440_04003
Adenine phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown.
  
 0.977
C440_07692
COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins.
  
 0.977
C440_14359
Adenine phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown.
  
 0.977
C440_01788
COG0516 IMP dehydrogenase/GMP reductase.
 
 0.969
C440_12159
Ham1 protein / nucleoside-triphosphatase; COG0127 Xanthosine triphosphate pyrophosphatase.
 
 
 0.950
surE-2
Acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.932
Your Current Organism:
Haloferax mucosum
NCBI taxonomy Id: 662479
Other names: H. mucosum ATCC BAA-1512, Haloferax mucosum ATCC BAA-1512, Haloferax mucosum JCM 14792, Haloferax mucosum PA12, Haloferax sp. PA12
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