STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purR_1Transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (334 aa)    
Predicted Functional Partners:
gltB
Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.710
ANP63716.1
Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.710
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 
 0.675
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 
 0.675
kbl
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
      
 0.645
atpB
F0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
      
 0.644
ANP67096.1
Bifunctional PTS fructose transporter subunit IIA/HPr protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.630
purD
Phosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family.
      
 0.589
ptsH
PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.568
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
   0.551
Your Current Organism:
Vibrio alginolyticus
NCBI taxonomy Id: 663
Other names: ATCC 17749, Beneckea alginolytica, CAIM 516, CCUG 13445, CCUG 16315, CCUG 4989, CIP 103336, CIP 75.3, DSM 2171, IFO 15630, LMG 4409, LMG:4409, NBRC 15630, NCCB 71013, NCCB 77003, NCTC 12160, Oceanomonas alginolytica, Pseudomonas creosotensis, V. alginolyticus, Vibrio sp. PeIg0901
Server load: low (38%) [HD]