STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU26925.1KEGG: cpy:Cphy_3096 isocitrate dehydrogenase (NAD(+)); PFAM: isocitrate/isopropylmalate dehydrogenase. (387 aa)    
Predicted Functional Partners:
ADU26926.1
KEGG: cth:Cthe_3158 aconitate hydratase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain-containing protein.
 0.985
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.936
ADU28192.1
KEGG: hmo:HM1_1037 glutamate synthase [nadph] large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein.
  
 
 0.921
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 0.906
ADU25819.1
PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: cbl:CLK_2865 putative 2-oxoacid:acceptor oxidoreductase, beta subunit.
   
 
 0.902
ADU25818.1
PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: ccu:Ccur_07880 2-oxoacid:ferredoxin oxidoreductase, gamma subunit.
     
  0.900
ADU25820.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: ele:Elen_1705 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
     
 0.900
ADU25821.1
KEGG: ccu:Ccur_07910 2-oxoglutarate ferredoxin oxidoreductase, delta subunit.
     
  0.900
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.864
ilvD
TIGRFAM: dihydroxy-acid dehydratase; KEGG: mta:Moth_2259 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.851
Your Current Organism:
Ethanoligenens harbinense
NCBI taxonomy Id: 663278
Other names: E. harbinense YUAN-3, Ethanoligenens harbinense YUAN-3, Ethanoligenens harbinense str. YUAN-3, Ethanoligenens harbinense strain YUAN-3
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.