| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | cca | REG_0275 | REG_1322 | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | 0.781 |
| birA | dapB | REG_0275 | REG_0859 | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.754 |
| birA | folK | REG_0275 | REG_1098 | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG0801; similar to AA sequence EcoGene EG11374; similar to AA sequence GI 157372222. | 0.688 |
| birA | metG | REG_0275 | REG_1379 | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Methionyl-tRNA synthetase; C terminal truncation; COG0143; similar to AA sequence EcoGene EG10586; similar to AA sequence GI 77975898. | 0.726 |
| birA | pcnB | REG_0275 | REG_1099 | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | poly(A) polymerase I; COG0617; similar to AA sequence EcoGene EG10690; similar to AA sequence GI 22124701. | 0.821 |
| cca | birA | REG_1322 | REG_0275 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.781 |
| cca | dapB | REG_1322 | REG_0859 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.645 |
| cca | metG | REG_1322 | REG_1379 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Methionyl-tRNA synthetase; C terminal truncation; COG0143; similar to AA sequence EcoGene EG10586; similar to AA sequence GI 77975898. | 0.727 |
| cca | pcnB | REG_1322 | REG_1099 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | poly(A) polymerase I; COG0617; similar to AA sequence EcoGene EG10690; similar to AA sequence GI 22124701. | 0.591 |
| cca | pnp | REG_1322 | REG_1169 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Polynucleotide phosphorylase/polyadenylase; COG1185; similar to AA sequence EcoGene EG10743; similar to AA sequence GI 22124608. | 0.631 |
| cca | rnr | REG_1322 | REG_0199 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | 0.423 |
| cca | smpA | REG_1322 | REG_0718 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Small protein A (tmRNA-binding); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.600 |
| cca | sspB | REG_1322 | REG_0260 | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | Stringent starvation protein B; COG2969; similar to AA sequence EcoGene EG10978; similar to AA sequence GI 123443921. | 0.678 |
| dapB | birA | REG_0859 | REG_0275 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.754 |
| dapB | cca | REG_0859 | REG_1322 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | COG0617; similar to AA sequence EcoGene EG10136; similar to AA sequence GI 77962302. | 0.645 |
| dapB | metG | REG_0859 | REG_1379 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | Methionyl-tRNA synthetase; C terminal truncation; COG0143; similar to AA sequence EcoGene EG10586; similar to AA sequence GI 77975898. | 0.475 |
| dapB | pcnB | REG_0859 | REG_1099 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | poly(A) polymerase I; COG0617; similar to AA sequence EcoGene EG10690; similar to AA sequence GI 22124701. | 0.645 |
| folK | birA | REG_1098 | REG_0275 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG0801; similar to AA sequence EcoGene EG11374; similar to AA sequence GI 157372222. | biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.688 |
| folK | pcnB | REG_1098 | REG_1099 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG0801; similar to AA sequence EcoGene EG11374; similar to AA sequence GI 157372222. | poly(A) polymerase I; COG0617; similar to AA sequence EcoGene EG10690; similar to AA sequence GI 22124701. | 0.930 |
| folK | sscR | REG_1098 | REG_1097 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG0801; similar to AA sequence EcoGene EG11374; similar to AA sequence GI 157372222. | 6-pyruvoyl-tetrahydropterin synthase (PTPS); COG0720; similar to AA sequence EcoGene EG13120; similar to AA sequence GI 22124730. | 0.576 |