STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA gyrase B subunit; COG0187; similar to AA sequence EcoGene EG10424; similar to AA sequence GI 77961786. (804 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.996
parC
Dimer of topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
 
 0.979
dnaN
DNA polymerase III beta subunit; COG0592; similar to AA sequence EcoGene EG10242; similar to AA sequence GI 226326919.
  
 
 0.766
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.719
dnaA
Chromosomal replication initiator protein and DNA-binding transcriptional dual regulator; COG0593; similar to AA sequence EcoGene EG10235; similar to AA sequence GI 77973772.
 
  
 0.676
pheT
Phenylalanine tRNA synthetase beta subunit; COG0072; similar to AA sequence EcoGene EG10710; similar to AA sequence GI 77975256; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.647
REG_1114
Pentapeptide repeat-containing protein; COG1357; similar to AA sequence EcoGene EG11941; similar to AA sequence GI 167771967.
    
 
 0.637
sopA
Type III secreted effector protein; Similar to AA sequence GI 162330071.
    
 
 0.629
recQ
ATP-dependent DNA helicase; COG0514; similar to AA sequence EcoGene EG10833; similar to AA sequence GI 77978530.
  
 
 0.575
metG
Methionyl-tRNA synthetase; C terminal truncation; COG0143; similar to AA sequence EcoGene EG10586; similar to AA sequence GI 77975898.
  
  
 0.540
Your Current Organism:
Regiella insecticola
NCBI taxonomy Id: 663321
Other names: C. Regiella insecticola LSR1, Candidatus Regiella insecticola LSR1, Candidatus Regiella insecticola str. LSR1, Candidatus Regiella insecticola strain LSR1
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