Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
REG_1603
Addiction module; Overlaps another CDS with the same product name. (84 aa)
Predicted Functional Partners:
REG_1602
Addiction module; COG3041; similar to AA sequence EcoGene EG13154; similar to AA sequence GI 226326732; overlaps another CDS with the same product name.
0.781
Your Current Organism:
Regiella insecticola
NCBI taxonomy Id: 663321 Other names: C. Regiella insecticola LSR1, Candidatus Regiella insecticola LSR1, Candidatus Regiella insecticola str. LSR1, Candidatus Regiella insecticola strain LSR1
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
REG_1602
REG_1603
Addiction module; COG3041; similar to AA sequence EcoGene EG13154; similar to AA sequence GI 226326732; overlaps another CDS with the same product name.
Addiction module; Overlaps another CDS with the same product name.
0.781
REG_1603
REG_1602
Addiction module; Overlaps another CDS with the same product name.
Addiction module; COG3041; similar to AA sequence EcoGene EG13154; similar to AA sequence GI 226326732; overlaps another CDS with the same product name.
0.781
Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: