STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KMO99764.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)    
Predicted Functional Partners:
KMO96592.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.962
KMO99723.1
M6 family metalloprotease domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.904
KMO99762.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.765
KMO98278.1
Phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.749
KMO97865.1
DNA primase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.660
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.651
KMO96461.1
DNA topoisomerase IV subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.651
KMO96982.1
DNA primase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.645
KMO96079.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.640
KMO98445.1
Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.630
Your Current Organism:
Streptomyces roseus
NCBI taxonomy Id: 66430
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.