Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KPL52394.1Modification methylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the N(4)/N(6)-methyltransferase family. (379 aa)    
Predicted Functional Partners:
lexA
LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
 0.882
KPL53231.1
Modification methylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.683
KPL55789.1
GcrA cell cycle regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.682
lon
DNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
     
 0.649
KPL53994.1
Cobalt chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.628
KPL53938.1
MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.574
KPL53995.1
Cobalamin biosynthesis protein CobS; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.552
KPL51962.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.550
atpF
ATP F0F1 synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family.
  
     0.516
KPL52393.1
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
       0.506
Your Current Organism:
Prosthecomicrobium hirschii
NCBI taxonomy Id: 665126
Other names: ATCC 27832, P. hirschii
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