ABB55_16830 protein (Prosthecomicrobium hirschii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ABB55_16830

Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)

Predicted Functional Partners:

KPL51086.1

0.500

KPL54268.1

0.447

trmB

0.446

KPL54172.1

0.436

KPL52702.1

0.416

Your Current Organism:

Prosthecomicrobium hirschii

NCBI taxonomy Id: 665126
Other names: ATCC 27832, P. hirschii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABB55_16830	KPL51086.1	ABB55_16830	ABB55_01670	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Lysophospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ABB55_16830	KPL52702.1	ABB55_16830	ABB55_11120	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.416
ABB55_16830	KPL54172.1	ABB55_16830	ABB55_19765	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.436
ABB55_16830	KPL54268.1	ABB55_16830	ABB55_20320	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
ABB55_16830	trmB	ABB55_16830	ABB55_10875	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	0.446
KPL51086.1	ABB55_16830	ABB55_01670	ABB55_16830	Lysophospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
KPL52702.1	ABB55_16830	ABB55_11120	ABB55_16830	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.416
KPL54172.1	ABB55_16830	ABB55_19765	ABB55_16830	RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.436
KPL54268.1	ABB55_16830	ABB55_20320	ABB55_16830	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.447
trmB	ABB55_16830	ABB55_10875	ABB55_16830	tRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.	Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.446

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.744

expected number of edges:

12

PPI enrichment p-value:

1.56e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

5 of 77

1.82

2.18

1.40e-05

GO:0005524

ATP binding

6 of 823

0.87

0.56

0.0152

GO:0043168

Anion binding

7 of 1447

0.69

0.44

0.0216

GO:0043167

Ion binding

9 of 2805

0.51

0.35

0.0216

GO:0005488

Binding

11 of 4994

0.35

0.27

0.0216

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071944

Cell periphery

6 of 826

0.87

0.47

0.0468

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15737

Type 1 protein exporter

4 of 5

2.91

3.74

1.31e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

5 of 162

1.49

1.66

4.79e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9754706

Atorvastatin ADME

4 of 18

2.35

2.83

3.33e-06

MAP-159418

Recycling of bile acids and salts

4 of 18

2.35

2.83

3.33e-06

MAP-983170

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

4 of 28

2.16

2.67

4.31e-06

MAP-382556

ABC-family proteins mediated transport

5 of 64

1.9

2.49

3.33e-06

MAP-9757110

Prednisone ADME

4 of 37

2.04

2.43

9.66e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 381

1.2

1.19

0.00017

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00664

ABC transporter transmembrane region

5 of 36

2.15

3.18

2.64e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039421

Type 1 protein exporter

5 of 12

2.63

4.31

6.13e-09

IPR036640

ABC transporter type 1, transmembrane domain superfamily

5 of 38

2.12

3.06

4.71e-07

IPR011527

ABC transporter type 1, transmembrane domain

5 of 38

2.12

3.06

4.71e-07

IPR017871

ABC transporter-like, conserved site

5 of 61

1.92

2.58

2.17e-06

IPR003439

ABC transporter-like, ATP-binding domain

5 of 70

1.86

2.45

3.33e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

5 of 142

1.55

1.71

5.34e-05

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