node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
M2SW06_COCSN | M2SZU6_COCSN | M2SW06 | M2SZU6 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Uncharacterized protein. | 0.791 |
M2SW06_COCSN | NCS2 | M2SW06 | M2RE08 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.769 |
M2SW06_COCSN | NCS6 | M2SW06 | M2RN96 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.441 |
M2SW06_COCSN | SPB1 | M2SW06 | M2S8C3 | Uncharacterized protein; Belongs to the DEAD box helicase family. | AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | 0.869 |
M2SW06_COCSN | YTM1 | M2SW06 | M2SHS3 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.896 |
M2SX06_COCSN | M2SYU9_COCSN | M2SX06 | M2SYU9 | ATP_bind_3 domain-containing protein. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | 0.614 |
M2SX06_COCSN | M2SZU6_COCSN | M2SX06 | M2SZU6 | ATP_bind_3 domain-containing protein. | Uncharacterized protein. | 0.457 |
M2SX06_COCSN | M2T6V0_COCSN | M2SX06 | M2T6V0 | ATP_bind_3 domain-containing protein. | PseudoU_synth_1 domain-containing protein. | 0.492 |
M2SX06_COCSN | NCS2 | M2SX06 | M2RE08 | ATP_bind_3 domain-containing protein. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.861 |
M2SYU9_COCSN | M2SX06_COCSN | M2SYU9 | M2SX06 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | ATP_bind_3 domain-containing protein. | 0.614 |
M2SYU9_COCSN | M2T6V0_COCSN | M2SYU9 | M2T6V0 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | PseudoU_synth_1 domain-containing protein. | 0.605 |
M2SYU9_COCSN | NCS2 | M2SYU9 | M2RE08 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.752 |
M2SYU9_COCSN | NCS6 | M2SYU9 | M2RN96 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.790 |
M2SYU9_COCSN | YTM1 | M2SYU9 | M2SHS3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.400 |
M2SYU9_COCSN | uba4 | M2SYU9 | M2QXC4 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.671 |
M2SZU6_COCSN | M2SW06_COCSN | M2SZU6 | M2SW06 | Uncharacterized protein. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.791 |
M2SZU6_COCSN | M2SX06_COCSN | M2SZU6 | M2SX06 | Uncharacterized protein. | ATP_bind_3 domain-containing protein. | 0.457 |
M2SZU6_COCSN | M2T6V0_COCSN | M2SZU6 | M2T6V0 | Uncharacterized protein. | PseudoU_synth_1 domain-containing protein. | 0.506 |
M2SZU6_COCSN | NCS2 | M2SZU6 | M2RE08 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.691 |
M2SZU6_COCSN | NCS6 | M2SZU6 | M2RN96 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. | 0.614 |