| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAC_0290 | ASAC_0292 | ASAC_0290 | ASAC_0292 | Putative HTH-type transcriptional regulator. | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.837 |
| ASAC_0290 | ASAC_0306 | ASAC_0290 | ASAC_0306 | Putative HTH-type transcriptional regulator. | Hypothetical protein. | 0.656 |
| ASAC_0290 | ASAC_0307 | ASAC_0290 | ASAC_0307 | Putative HTH-type transcriptional regulator. | DUF75 domain containing protein. | 0.530 |
| ASAC_0290 | ASAC_1377 | ASAC_0290 | ASAC_1377 | Putative HTH-type transcriptional regulator. | DUF99 domain containing protein; Belongs to the UPF0215 family. | 0.503 |
| ASAC_0290 | hflX | ASAC_0290 | ASAC_0291 | Putative HTH-type transcriptional regulator. | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.922 |
| ASAC_0290 | nac | ASAC_0290 | ASAC_0543 | Putative HTH-type transcriptional regulator. | Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.695 |
| ASAC_0290 | pan | ASAC_0290 | ASAC_0295 | Putative HTH-type transcriptional regulator. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.767 |
| ASAC_0290 | tfe | ASAC_0290 | ASAC_0293 | Putative HTH-type transcriptional regulator. | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] | 0.875 |
| ASAC_0292 | ASAC_0290 | ASAC_0292 | ASAC_0290 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative HTH-type transcriptional regulator. | 0.837 |
| ASAC_0292 | ASAC_0306 | ASAC_0292 | ASAC_0306 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Hypothetical protein. | 0.701 |
| ASAC_0292 | hflX | ASAC_0292 | ASAC_0291 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.917 |
| ASAC_0292 | nac | ASAC_0292 | ASAC_0543 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. | 0.693 |
| ASAC_0292 | pan | ASAC_0292 | ASAC_0295 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.562 |
| ASAC_0292 | tfe | ASAC_0292 | ASAC_0293 | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] | 0.929 |
| ASAC_0305 | ASAC_0306 | ASAC_0305 | ASAC_0306 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Hypothetical protein. | 0.570 |
| ASAC_0305 | ASAC_0307 | ASAC_0305 | ASAC_0307 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | DUF75 domain containing protein. | 0.570 |
| ASAC_0306 | ASAC_0290 | ASAC_0306 | ASAC_0290 | Hypothetical protein. | Putative HTH-type transcriptional regulator. | 0.656 |
| ASAC_0306 | ASAC_0292 | ASAC_0306 | ASAC_0292 | Hypothetical protein. | Hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.701 |
| ASAC_0306 | ASAC_0305 | ASAC_0306 | ASAC_0305 | Hypothetical protein. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.570 |
| ASAC_0306 | ASAC_0307 | ASAC_0306 | ASAC_0307 | Hypothetical protein. | DUF75 domain containing protein. | 0.878 |