Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
ASAC_1235Serine hydroxymethyltransferase. (433 aa)    
Predicted Functional Partners:
ASAC_0569
Glycine cleavage system aminomethyltransferase T.
 
 0.998
gcvPB
Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
 
 
 0.988
gcvPA
Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
 
 0.981
gcvH
Probable glycine cleavage system H protein 1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.981
ASAC_0818
Phosphoserine phosphatase.
 
 0.969
ASAC_0793
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit.
  
 
 0.965
thyX
Predicted alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
   
 0.947
ASAC_1063
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide E3 component-like enzyme; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 
 0.944
ASAC_1316
Threonine dehydratase.
  
 
 0.944
ASAC_1371
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide E3 component-like enzyme; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 
 
 0.944
Your Current Organism:
Acidilobus saccharovorans
NCBI taxonomy Id: 666510
Other names: A. saccharovorans 345-15, Acidilobus saccharovorans 345-15, Acidilobus saccharovorans str. 345-15, Acidilobus saccharovorans strain 345-15, Acidilobus sp. 345-15
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