| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASAC_0429 | ASAC_1343 | ASAC_0429 | ASAC_1343 | Signal peptidase. | O-methyltransferase, family 3. | 0.434 |
| ASAC_0429 | pan | ASAC_0429 | ASAC_0295 | Signal peptidase. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.427 |
| ASAC_0567 | ASAC_1343 | ASAC_0567 | ASAC_1343 | Fumarylacetoacetate hydrolase family protein. | O-methyltransferase, family 3. | 0.436 |
| ASAC_0567 | ASAC_1440 | ASAC_0567 | ASAC_1440 | Fumarylacetoacetate hydrolase family protein. | Succinate:quinone oxidoreductase, iron-sulfur subunit B. | 0.838 |
| ASAC_0567 | ASAC_1443 | ASAC_0567 | ASAC_1443 | Fumarylacetoacetate hydrolase family protein. | Succinate:quinone oxidoreductase, flavoprotein subunit A. | 0.889 |
| ASAC_0720 | ASAC_0973 | ASAC_0720 | ASAC_0973 | Putative methyltransferase. | Hypothetical protein. | 0.413 |
| ASAC_0720 | ASAC_1343 | ASAC_0720 | ASAC_1343 | Putative methyltransferase. | O-methyltransferase, family 3. | 0.427 |
| ASAC_0973 | ASAC_0720 | ASAC_0973 | ASAC_0720 | Hypothetical protein. | Putative methyltransferase. | 0.413 |
| ASAC_0973 | ASAC_1343 | ASAC_0973 | ASAC_1343 | Hypothetical protein. | O-methyltransferase, family 3. | 0.411 |
| ASAC_1201 | ASAC_1343 | ASAC_1201 | ASAC_1343 | hemD uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | O-methyltransferase, family 3. | 0.470 |
| ASAC_1343 | ASAC_0429 | ASAC_1343 | ASAC_0429 | O-methyltransferase, family 3. | Signal peptidase. | 0.434 |
| ASAC_1343 | ASAC_0567 | ASAC_1343 | ASAC_0567 | O-methyltransferase, family 3. | Fumarylacetoacetate hydrolase family protein. | 0.436 |
| ASAC_1343 | ASAC_0720 | ASAC_1343 | ASAC_0720 | O-methyltransferase, family 3. | Putative methyltransferase. | 0.427 |
| ASAC_1343 | ASAC_0973 | ASAC_1343 | ASAC_0973 | O-methyltransferase, family 3. | Hypothetical protein. | 0.411 |
| ASAC_1343 | ASAC_1201 | ASAC_1343 | ASAC_1201 | O-methyltransferase, family 3. | hemD uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.470 |
| ASAC_1343 | ASAC_1344 | ASAC_1343 | ASAC_1344 | O-methyltransferase, family 3. | Hypothetical protein. | 0.509 |
| ASAC_1343 | ASAC_1440 | ASAC_1343 | ASAC_1440 | O-methyltransferase, family 3. | Succinate:quinone oxidoreductase, iron-sulfur subunit B. | 0.412 |
| ASAC_1343 | ASAC_1443 | ASAC_1343 | ASAC_1443 | O-methyltransferase, family 3. | Succinate:quinone oxidoreductase, flavoprotein subunit A. | 0.453 |
| ASAC_1343 | pan | ASAC_1343 | ASAC_0295 | O-methyltransferase, family 3. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.560 |
| ASAC_1343 | speE | ASAC_1343 | ASAC_1269 | O-methyltransferase, family 3. | Probable spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. | 0.428 |