gcaD protein (Bacillus clausii) - STRING interaction network

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gcaD

UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (454 aa)

Predicted Functional Partners:

glmM

0.984

murA

0.973

prs

0.964

murZ

0.959

galE

0.949

ABC0514

0.928

glmS

0.912

ABC0508

0.908

ABC3098

0.899

gtaB

0.898

Your Current Organism:

Bacillus clausii

NCBI taxonomy Id: 66692
Other names: B. clausii KSM-K16, Bacillus clausii KSM-K16, Bacillus sp. (strain KSM-K16), Bacillus sp. KSM-K16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABC0508	ABC0514	ABC0508	ABC0514	UDP-glucose 4-epimerase.	UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.967
ABC0508	ABC3098	ABC0508	ABC3098	UDP-glucose 4-epimerase.	UTP-glucose-1-phosphate uridylyltransferase.	0.862
ABC0508	galE	ABC0508	ABC3822	UDP-glucose 4-epimerase.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.922
ABC0508	gcaD	ABC0508	ABC0078	UDP-glucose 4-epimerase.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	0.908
ABC0508	gtaB	ABC0508	ABC3698	UDP-glucose 4-epimerase.	UTP-glucose-1-phosphate uridylyltransferase.	0.861
ABC0508	murA	ABC0508	ABC3847	UDP-glucose 4-epimerase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.905
ABC0508	murZ	ABC0508	ABC3881	UDP-glucose 4-epimerase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.905
ABC0514	ABC0508	ABC0514	ABC0508	UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	UDP-glucose 4-epimerase.	0.967
ABC0514	gcaD	ABC0514	ABC0078	UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	0.928
ABC3098	ABC0508	ABC3098	ABC0508	UTP-glucose-1-phosphate uridylyltransferase.	UDP-glucose 4-epimerase.	0.862
ABC3098	galE	ABC3098	ABC3822	UTP-glucose-1-phosphate uridylyltransferase.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.949
ABC3098	gcaD	ABC3098	ABC0078	UTP-glucose-1-phosphate uridylyltransferase.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	0.899
ABC3098	glmM	ABC3098	ABC0243	UTP-glucose-1-phosphate uridylyltransferase.	Phosphoglucomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.412
ABC3098	glmS	ABC3098	ABC0245	UTP-glucose-1-phosphate uridylyltransferase.	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.496
ABC3098	gtaB	ABC3098	ABC3698	UTP-glucose-1-phosphate uridylyltransferase.	UTP-glucose-1-phosphate uridylyltransferase.	0.901
ABC3098	murA	ABC3098	ABC3847	UTP-glucose-1-phosphate uridylyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.829
ABC3098	murZ	ABC3098	ABC3881	UTP-glucose-1-phosphate uridylyltransferase.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.829
galE	ABC0508	ABC3822	ABC0508	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	UDP-glucose 4-epimerase.	0.922
galE	ABC3098	ABC3822	ABC3098	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	UTP-glucose-1-phosphate uridylyltransferase.	0.949
galE	gcaD	ABC3822	ABC0078	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	0.949

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