| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpP | phoR | ABC3026 | ABC2710 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP2 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | Two-component sensor histidine kinase. | 0.468 |
| clpP | sigW | ABC3026 | ABC0239 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP2 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.515 |
| dacA-2 | rsiW | ABC0241 | ABC0240 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | Anti-sigma factor; Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation (By similarity); Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family. | 0.532 |
| dacA-2 | sigW | ABC0241 | ABC0239 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.507 |
| mlpA | rasP | ABC2220 | ABC2235 | Zn-dependent protease; Belongs to the peptidase M16 family. | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | 0.491 |
| mlpA | sigW | ABC2220 | ABC0239 | Zn-dependent protease; Belongs to the peptidase M16 family. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.530 |
| phoR | clpP | ABC2710 | ABC3026 | Two-component sensor histidine kinase. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP2 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | 0.468 |
| phoR | sigW | ABC2710 | ABC0239 | Two-component sensor histidine kinase. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.579 |
| prsW | rasP | ABC1865 | ABC2235 | Conserved hypothetical protein; Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | 0.552 |
| prsW | rsiW | ABC1865 | ABC0240 | Conserved hypothetical protein; Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Anti-sigma factor; Is the anti-sigma factor for SigW. The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation (By similarity); Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family. | 0.616 |
| prsW | sigW | ABC1865 | ABC0239 | Conserved hypothetical protein; Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.580 |
| prsW | sppA | ABC1865 | ABC2747 | Conserved hypothetical protein; Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Signal peptidase SppA. | 0.520 |
| rasP | mlpA | ABC2235 | ABC2220 | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Zn-dependent protease; Belongs to the peptidase M16 family. | 0.491 |
| rasP | prsW | ABC2235 | ABC1865 | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Conserved hypothetical protein; Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | 0.552 |
| rasP | sigW | ABC2235 | ABC0239 | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.509 |
| rasP | sppA | ABC2235 | ABC2747 | Zn-dependent protease; Is responsible for Site-2 cleavage of the RsiW anti-sigma factor. This results, after a third proteolytic step catalyzed by the ClpXP protease, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity). | Signal peptidase SppA. | 0.552 |
| rpoB | rpoC | ABC0142 | ABC0143 | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoB | sigW | ABC0142 | ABC0239 | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.526 |
| rpoC | rpoB | ABC0143 | ABC0142 | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoC | sigW | ABC0143 | ABC0239 | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase ECF-type sigma factor sigma-W; Belongs to the sigma-70 factor family. ECF subfamily. | 0.567 |