STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigBDNA-directed RNA polymerase general stress sigma factor sigma-B; Belongs to the sigma-70 factor family. (261 aa)    
Predicted Functional Partners:
rsbW
Anti-sigma B factor; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
 
 
 0.971
rsbU
Indirect positive regulator of sigma-B activity.
 
 
 0.932
rsbV
Positive regulator of sigma-B activity; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.921
rsbX
Indirect negative regulator of sigma-B activity.
 
 
 0.874
rsbT
Positive regulator of sigma-B activity.
 
 
 0.846
spoIIAA
Stage II sporulation protein AA, anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.812
flgM
Negative regulator of flagellin synthesis.
  
 
 0.795
ABC2609
General stress protein GSP18.
   
  
 0.791
cheV
Chemotaxis protein CheV.
  
  
 0.789
rsbS
Negative regulator of sigma-B activity.
 
 
 0.768
Your Current Organism:
Bacillus clausii
NCBI taxonomy Id: 66692
Other names: B. clausii KSM-K16, Bacillus clausii KSM-K16, Bacillus sp. (strain KSM-K16), Bacillus sp. KSM-K16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.