node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABC1167 | ABC1168 | ABC1167 | ABC1168 | Transcriptional regulator. | Histidinol dehydrogenase. | 0.697 |
ABC1168 | ABC1167 | ABC1168 | ABC1167 | Histidinol dehydrogenase. | Transcriptional regulator. | 0.697 |
ABC1168 | hisA | ABC1168 | ABC3045 | Histidinol dehydrogenase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.963 |
ABC1168 | hisB | ABC1168 | ABC3047 | Histidinol dehydrogenase. | Imidazoleglycerol-phosphate dehydratase. | 0.976 |
ABC1168 | hisC | ABC1168 | ABC1901 | Histidinol dehydrogenase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.947 |
ABC1168 | hisF | ABC1168 | ABC3044 | Histidinol dehydrogenase. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.981 |
ABC1168 | hisG | ABC1168 | ABC3049 | Histidinol dehydrogenase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.932 |
ABC1168 | hisH | ABC1168 | ABC3046 | Histidinol dehydrogenase. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.957 |
ABC1168 | hisI | ABC1168 | ABC3043 | Histidinol dehydrogenase. | Bifunctional histidine biosynthesis protein HisJ; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
ABC1168 | hisJ | ABC1168 | ABC2752 | Histidinol dehydrogenase. | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.677 |
ABC1168 | hisZ | ABC1168 | ABC3050 | Histidinol dehydrogenase. | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.812 |
hisA | ABC1168 | ABC3045 | ABC1168 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase. | 0.963 |
hisA | hisB | ABC3045 | ABC3047 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.996 |
hisA | hisC | ABC3045 | ABC1901 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.956 |
hisA | hisF | ABC3045 | ABC3044 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | ABC3045 | ABC3049 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisA | hisH | ABC3045 | ABC3046 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | ABC3045 | ABC3043 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Bifunctional histidine biosynthesis protein HisJ; phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | ABC3045 | ABC3050 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.978 |
hisB | ABC1168 | ABC3047 | ABC1168 | Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase. | 0.976 |