STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIIABStage II sporulation protein AB; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (146 aa)    
Predicted Functional Partners:
spoIIAA
Stage II sporulation protein AA, anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.995
sigF
DNA-directed RNA polymerase sigma factor sigma-F; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 
 0.978
spoIIGA
Sporulation sigma-E factor processing peptidase; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
  
  
 0.921
sigG
DNA-directed RNA polymerase sigma factor sigma-G; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.909
spoIIR
Stage II sporulation protein R.
  
   
 0.906
spoIIID
Stage III sporulation protein D.
  
   
 0.891
spoVT
Transcriptional regulator stage V sporulation protein T.
  
   
 0.889
spo0A
Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
 
  
 0.887
ABC1796
Stage V sporulation protein AC.
 
   
 0.868
ABC1797
Stage V sporulation protein AD.
 
  
 0.863
Your Current Organism:
Bacillus clausii
NCBI taxonomy Id: 66692
Other names: B. clausii KSM-K16, Bacillus clausii KSM-K16, Bacillus sp. (strain KSM-K16), Bacillus sp. KSM-K16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.