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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH43953.1COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790; KEGG: gem:GM21_0770 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; IMG reference gene:2505283350; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit. (364 aa)    
Predicted Functional Partners:
AEH44875.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.990
AEH45882.1
COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR003141:IPR 004805; KEGG: dak:DaAHT2_1400 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2505285368; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DN [...]
  
 0.989
AEH44468.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR004622; KEGG: pca:Pcar_1692 DNA polymerase III, gamma/tau subunits; SPTR: DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta prime subunit; IMG reference gene:2505283882; TIGRFAM: DNA polymerase III, delta' subunit.
 
 
 0.986
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.982
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.707
AEH44051.1
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477:IPR004797; KEGG: nwa:Nwat_0444 DNA internalization-like competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; IMG reference gene:2505283449; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence p [...]
 
   
 0.668
AEH45662.1
Hypothetical protein; InterPro IPR019734:IPR013026; KEGG: dak:DaAHT2_1194 tetratricopeptide TPR_4; SPTR: Tetratricopeptide TPR_4; IMG reference gene:2505285133.
 
     0.558
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
      
 0.534
AEH43952.1
DnaJ like protein; InterPro IPR018961; KEGG: drt:Dret_1391 DnaJ-like, subfamily C, member 28; PFAM: DnaJ homologue, subfamily C, member 28, conserved domain; SPTR: DnaJ-like, subfamily C, member 28; IMG reference gene:2505283349; PFAM: Domain of unknown function (DUF1992).
       0.531
AEH45989.1
Hypothetical protein; KEGG: dol:Dole_3051 response regulator receiver protein; SPTR: Response regulator receiver protein; IMG reference gene:2505285478.
  
     0.523
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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