Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH43964.1COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: dat:HRM2_25100 response regulator family protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Hypothetical histidine kinase protein; IMG reference gene:2505283361; PFAM: Response regulator receiver domain. (126 aa)    
Predicted Functional Partners:
AEH43965.1
Transcription regulator AsnC-type; InterPro IPR019887; KEGG: sma:SAV_2677 hypothetical protein; PFAM: Transcription regulator AsnC-type-like; SPTR: Putative AsnC-family transcriptional regulator; IMG reference gene:2505283362; PFAM: AsnC family.
       0.778
AEH45731.1
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR004358:IPR003661:IPR003594:IPR005467; KEGG: drm:Dred_1311 sensory histidine kinase AtoS; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Signal transduction histidine-protein kinase atoS; IMG reference gene:2505285206; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
   0.776
AEH44293.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR013767:IPR003661:IPR003594:IPR 004358:IPR005467:IPR000700; KEGG: tye:THEYE_A0125 sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensor histidine kinase; TIGRFAM: PAS sensor protein; IMG reference gene:2505283700; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like [...]
 
 
 
 0.755
AEH45913.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR004358:IPR003660:IPR003661:IPR003594:IPR 005467; KEGG: dvm:DvMF_0701 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Integral membrane sensor signal transduction histidine kinase; IMG reference gene:2505285400; PFAM: Histidine kinase-, DNA gyrase B-, [...]
  
 
   0.753
AEH44786.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR003594:IPR 004358; KEGG: cts:Ctha_2235 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; response regulator receiver; SPTR: PAS/PAC sensor hybrid histidine kinase; IMG reference gene:2505284216; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain.
 
 
 0.741
AEH45001.1
Histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR003661:IPR003594:IPR004358:IPR005467; KEGG: dma:DMR_02390 two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Cell cycle histidine kinase CckA; IMG reference gene:2505284442; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
 
   0.732
AEH44013.1
Histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR004358:IPR003594:IPR005467; KEGG: dak:DaAHT2_2152 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensory box histidine kinase/response regulator; IMG reference gene:2505283411; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
   0.729
AEH44277.1
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR004358:IPR005467; KEGG: drt:Dret_0468 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Sensory box histidine kinase PhoR; IMG reference gene:2505283684; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
 
   0.728
AEH46067.1
Integral membrane sensor signal transduction histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR003660:IPR003661:IPR003594:IPR004358:IPR 005467:IPR009056; KEGG: dba:Dbac_2092 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SPTR: Histidine kinase; IMG reference gene:2505285558; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, [...]
  
     0.724
AEH44932.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR003661:IPR003594:IPR004358:IPR 013767:IPR005467; KEGG: sfu:Sfum_2495 signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; histidine kinase A domain protein; SPTR: PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: PAS sensor protein; IMG reference gene:2505284371; [...]
  
   0.723
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (44%) [HD]