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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44085.1Proposed homoserine kinase; COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR019304:IPR006124:IPR013371:IPR004456; KEGG: tye:THEYE_A1682 proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Proposed homoserine kinase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; IMG reference gene:2505283483; PFAM: Metalloenzyme superfamily; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; TIGRFAM: 2,3-bisphosphoglycerate-ind [...] (408 aa)    
Predicted Functional Partners:
AEH45865.1
Phosphonopyruvate decarboxylase-related protein; COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR004456:IPR019304:IPR006124; KEGG: dak:DaAHT2_2657 phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Cofactor-independent phosphoglycerate mutase, archaeal; TIGRFAM: phosphonopyruvate decarboxylase-related protein; IMG reference gene:2505285351; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGR [...]
  
  
 
0.925
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.913
pgk
COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576:IPR015911; KEGG: dak:DaAHT2_0036 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; IMG reference gene:2505284726; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
    
 0.910
gpmI
Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
     
 0.909
AEH44732.1
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140:IPR002912:IPR006236; KEGG: dak:DaAHT2_0597 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; IMG reference gene:2505284157; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D- [...]
    
  0.900
AEH43934.1
Phosphoglucose isomerase (PGI); COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR001672; KEGG: srm:SRM_00085 putative transaldolase phosphoglucose isomerase; PFAM: phosphoglucose isomerase (PGI); SPTR: Putative Transaldolase Phosphoglucose isomerase; IMG reference gene:2505283331; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
   
 
 0.818
fbp
Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.816
AEH44437.1
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
     
 0.805
rnhA
Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
     
  0.800
AEH44364.1
Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
    
  0.800
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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