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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.990
AEH44116.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.917
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.910
cas2-3
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.905
AEH44114.1
Metal dependent phosphohydrolase; COGs: COG1203 helicase; InterProIPR006674:IPR011545:IPR001650:IPR014021:IPR 006483:IPR006474:IPR003607:IPR014001; KEGG: dau:Daud_1813 metal dependent phosphohydrolase; PFAM: DEAD/DEAH box helicase domain protein; metal-dependent phosphohydrolase HD sub domain; helicase domain protein; SMART: DEAD-like helicase; metal-dependent phosphohydrolase HD region; helicase domain protein; SPTR: Metal dependent phosphohydrolase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; IMG reference gene:2505283513; PFAM: HD domain; DEAD/DEAH [...]
 
  
 0.805
AEH44101.1
CRISPR-associated protein Cas6; COGs: COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR002743:IPR010156; KEGG: rxy:Rxyl_0271 CRISPR-associated Cas6 family protein; PFAM: protein of unknown function DUF57; SPTR: CRISPR-associated protein, Cas6 family; TIGRFAM: CRISPR-associated protein Cas6; IMG reference gene:2505283500; PFAM: CRISPR associated protein Cas6; TIGRFAM: CRISPR-associated endoribonuclease Cas6.
 
   
 0.776
AEH44112.1
CRISPR-associated autoregulator, DevR family; COGs: COG1857 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR010154:IPR013414; KEGG: tte:TTE2662 hypothetical protein; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated regulatory protein, DevR family; CRISPR-associated autoregulator DevR family; IMG reference gene:2505283511; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP.
 
   
 0.629
AEH45209.1
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013410:IPR005537; KEGG: sat:SYN_02249 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical exported protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; IMG reference gene:2505284656; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr4.
 
   
 0.581
AEH44032.1
COGs: COG0248 Exopolyphosphatase; InterPro IPR000119:IPR003695; KEGG: tye:THEYE_A1046 bifunctional 3-dehydroquinate synthase/phosphatase; PFAM: Ppx/GppA phosphatase; histone family protein DNA-binding protein; SMART: histone family protein DNA-binding protein; SPTR: Bifunctional 3-dehydroquinate synthase/phosphatase; IMG reference gene:2505283430; PFAM: Bacterial DNA-binding protein; Ppx/GppA phosphatase family.
    
   0.544
AEH45207.1
CRISPR-associated RAMP protein, Cmr6 family; COGs: COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR010172:IPR005537; KEGG: sat:SYN_02247 putative cytoplasmic protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical cytosolic protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; IMG reference gene:2505284654; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr6.
 
     0.540
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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