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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hypAHydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (116 aa)    
Predicted Functional Partners:
AEH44178.1
Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003495:IPR004392:IPR012202; KEGG: pmx:PERMA_0918 hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: Hydrogenase accessory protein HypB; TIGRFAM: hydrogenase accessory protein HypB; IMG reference gene:2505283583; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB.
 
 
 0.986
AEH44173.1
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR001501:IPR018194; KEGG: dps:DP0575 Ni/Fe-hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Probable Ni/Fe-hydrogenase, large subunit; IMG reference gene:2505283578; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.969
AEH44175.1
COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671; KEGG: tjr:TherJR_0260 hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; SPTR: Hydrogenase maturation protease; TIGRFAM: hydrogenase maturation protease; IMG reference gene:2505283580; PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase expression/formation protein; hydrogenase maturation protease.
 
  
 0.945
AEH44179.1
(NiFe) hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterProIPR001792:IPR011125:IPR006070:IPR004421:IPR 017968; KEGG: sat:SYN_00600 hydrogenase maturation protein; PFAM: SUA5/yciO/yrdC domain; acylphosphatase; SPTR: Hydrogenase maturation protein; TIGRFAM: [NiFe] hydrogenase maturation protein HypF; IMG reference gene:2505283584; PFAM: HypF finger; yrdC domain; Glycoprotease family; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF.
 
   
 0.912
AEH44174.1
COGs: COG1740 Ni Fe-hydrogenase I small subunit; InterPro IPR001821:IPR006137:IPR017909:IPR006311; KEGG: dps:DP0574 Ni/Fe-hydrogenase, small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; PRIAM: Hydrogenase (acceptor); SPTR: Probable Ni/Fe-hydrogenase, small subunit; TIGRFAM: hydrogenase (NiFe) small subunit HydA; IMG reference gene:2505283579; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: hydrogenase (NiFe) small subunit (hydA); Tat (twin-arginine translocation) pathway signal sequence.
 
  
 0.911
AEH44176.1
Hydrogenase assembly chaperone hypC/hupF; COGs: COG0298 Hydrogenase maturation factor; InterPro IPR001109:IPR019812; KEGG: glo:Glov_3064 hydrogenase assembly chaperone HypC/HupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); SPTR: Hydrogenase assembly chaperone hypC/hupF; TIGRFAM: hydrogenase assembly chaperone hypC/hupF; IMG reference gene:2505283581; PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
  
 0.896
AEH44172.1
COGs: COG1969 Ni Fe-hydrogenase I cytochrome b subunit; InterPro IPR000516; KEGG: dps:DP0576 Ni/Fe-hydrogenase, cytochrome subunit; SPTR: Probable Ni/Fe-hydrogenase, cytochrome subunit; TIGRFAM: Ni/Fe-hydrogenase, b-type cytochrome subunit; IMG reference gene:2505283577; PFAM: Cytochrome b(N-terminal)/b6/petB; TIGRFAM: Ni/Fe-hydrogenase, b-type cytochrome subunit.
 
   
 0.856
AEH45679.1
Polyferredoxin; InterPro IPR017896:IPR017900; KEGG: dps:DP1772 polyferredoxins; SPTR: Related to polyferredoxins; IMG reference gene:2505285150; PFAM: 4Fe-4S binding domain.
  
  
 0.708
AEH45861.1
Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: gsu:GSU0308 hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: hydrogenase expression/formation protein HypD; IMG reference gene:2505285346; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD.
 
  
 0.617
AEH45769.1
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR011854:IPR000728:IPR010918; KEGG: ana:alr0698 hydrogenase expression/formation protein; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; SPTR: Hydrogenase expression/formation protein; TIGRFAM: hydrogenase expression/formation protein HypE; IMG reference gene:2505285249; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
  
 0.608
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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