close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44178.1Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003495:IPR004392:IPR012202; KEGG: pmx:PERMA_0918 hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: Hydrogenase accessory protein HypB; TIGRFAM: hydrogenase accessory protein HypB; IMG reference gene:2505283583; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB. (225 aa)    
Predicted Functional Partners:
hypA
Hydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.986
AEH44176.1
Hydrogenase assembly chaperone hypC/hupF; COGs: COG0298 Hydrogenase maturation factor; InterPro IPR001109:IPR019812; KEGG: glo:Glov_3064 hydrogenase assembly chaperone HypC/HupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); SPTR: Hydrogenase assembly chaperone hypC/hupF; TIGRFAM: hydrogenase assembly chaperone hypC/hupF; IMG reference gene:2505283581; PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
  
 0.965
AEH44179.1
(NiFe) hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterProIPR001792:IPR011125:IPR006070:IPR004421:IPR 017968; KEGG: sat:SYN_00600 hydrogenase maturation protein; PFAM: SUA5/yciO/yrdC domain; acylphosphatase; SPTR: Hydrogenase maturation protein; TIGRFAM: [NiFe] hydrogenase maturation protein HypF; IMG reference gene:2505283584; PFAM: HypF finger; yrdC domain; Glycoprotease family; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF.
 
   
 0.954
AEH45861.1
Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: gsu:GSU0308 hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: hydrogenase expression/formation protein HypD; IMG reference gene:2505285346; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD.
 
  
 0.927
AEH44175.1
COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671; KEGG: tjr:TherJR_0260 hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; SPTR: Hydrogenase maturation protease; TIGRFAM: hydrogenase maturation protease; IMG reference gene:2505283580; PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase expression/formation protein; hydrogenase maturation protease.
 
  
 0.880
AEH45769.1
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR011854:IPR000728:IPR010918; KEGG: ana:alr0698 hydrogenase expression/formation protein; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; SPTR: Hydrogenase expression/formation protein; TIGRFAM: hydrogenase expression/formation protein HypE; IMG reference gene:2505285249; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
  
 0.830
AEH44173.1
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR001501:IPR018194; KEGG: dps:DP0575 Ni/Fe-hydrogenase, large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: Probable Ni/Fe-hydrogenase, large subunit; IMG reference gene:2505283578; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.821
AEH44174.1
COGs: COG1740 Ni Fe-hydrogenase I small subunit; InterPro IPR001821:IPR006137:IPR017909:IPR006311; KEGG: dps:DP0574 Ni/Fe-hydrogenase, small subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; PRIAM: Hydrogenase (acceptor); SPTR: Probable Ni/Fe-hydrogenase, small subunit; TIGRFAM: hydrogenase (NiFe) small subunit HydA; IMG reference gene:2505283579; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: hydrogenase (NiFe) small subunit (hydA); Tat (twin-arginine translocation) pathway signal sequence.
 
  
 0.810
ureA
Urease, gamma subunit; COGs: COG0831 Urea amidohydrolase (urease) gamma subunit; InterPro IPR012010:IPR002026; KEGG: tjr:TherJR_0605 urease, gamma subunit; PFAM: Urease gamma subunit region; PRIAM: Urease; SPTR: Urease subunit gamma; TIGRFAM: urease, gamma subunit; IMG reference gene:2505284450; PFAM: Urease, gamma subunit; TIGRFAM: urease, gamma subunit.
 
  
 0.806
ureC
Urease, alpha subunit; COGs: COG0804 Urea amidohydrolase (urease) alpha subunit; InterProIPR017950:IPR005848:IPR017952:IPR011612:IPR 006680:IPR017951; KEGG: tjr:TherJR_0607 urease, alpha subunit; PFAM: amidohydrolase; Urease alpha-subunit domain-containing protein; PRIAM: Urease; SPTR: Urease subunit alpha; TIGRFAM: urease, alpha subunit; IMG reference gene:2505284448; PFAM: Urease alpha-subunit, N-terminal domain; Amidohydrolase family; TIGRFAM: urease, alpha subunit.
  
  
 0.782
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.