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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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AEH44188.1InterPro IPR001623:IPR003095; KEGG: mhu:Mhun_0257 heat shock protein DnaJ-like; PFAM: heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein; SPTR: Heat shock protein DnaJ-like; IMG reference gene:2505283593; PFAM: DnaJ domain. (100 aa)    
Predicted Functional Partners:
AEH44187.1
COGs: COG0527 Aspartokinase; InterProIPR005260:IPR001341:IPR001048:IPR002912:IPR 001057:IPR018042; KEGG: pca:Pcar_1006 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; IMG reference gene:2505283592; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family.
       0.818
AEH44186.1
2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005675:IPR002034; KEGG: sfu:Sfum_2174 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; IMG reference gene:2505283591; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthas [...]
   
   0.811
AEH44185.1
Cobyrinic acid ac-diamide synthase; COGs: COG3640 CO dehydrogenase maturation factor; InterPro IPR014433; KEGG: dak:DaAHT2_1179 cobyrinic acid ac-diamide synthase; SPTR: Cobyrinic acid a,c-diamide synthase; IMG reference gene:2505283590; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
       0.805
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.729
AEH44421.1
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR013126:IPR001023:IPR018181; KEGG: dal:Dalk_0767 DnaK-related protein; PFAM: Heat shock protein 70; SPTR: DnaK-related protein; IMG reference gene:2505283834; PFAM: DNA-K related protein; Hsp70 protein.
  
 0.670
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.670
AEH45780.1
Hypothetical protein; KEGG: sat:SYN_01836 MreB-like ATPase involved in cell division; SPTR: Putative uncharacterized protein; IMG reference gene:2505285261.
  
 0.670
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.666
AEH44933.1
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0492 Thioredoxin reductase; InterPro IPR000103:IPR013027:IPR001327; KEGG: tye:THEYE_A0446 oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Oxidoreductase; IMG reference gene:2505284372; PFAM: Pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.630
AEH44504.1
KEGG: dak:DaAHT2_2406 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283918.
  
     0.615
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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