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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44192.1Radical SAM domain protein; COGs: COG1032 Fe-S oxidoreductase; InterProIPR006158:IPR007197:IPR019734:IPR013026:IPR 006638; KEGG: dal:Dalk_4123 radical SAM domain protein; PFAM: Radical SAM domain protein; cobalamin B12-binding domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; IMG reference gene:2505283597; PFAM: Radical SAM superfamily; B12 binding domain. (577 aa)    
Predicted Functional Partners:
AEH44193.1
Radical SAM domain protein; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197:IPR006638; KEGG: sfu:Sfum_3475 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; IMG reference gene:2505283598; PFAM: Radical SAM superfamily.
 
    
0.579
AEH45994.1
Peptidase M23; COGs: COG4942 Membrane-bound metallopeptidase; InterPro IPR016047; KEGG: glo:Glov_1921 peptidase M23; PFAM: Peptidase M23; SPTR: Peptidase M23; IMG reference gene:2505285483; PFAM: Peptidase family M23.
   
   0.562
AEH45611.1
NAD-dependent epimerase/dehydratase; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR001509; KEGG: mno:Mnod_5601 oxidoreductase domain protein; PFAM: NAD-dependent epimerase/dehydratase; oxidoreductase domain protein; SPTR: Oxidoreductase domain protein; IMG reference gene:2505285078; PFAM: NAD dependent epimerase/dehydratase family; Oxidoreductase family, NAD-binding Rossmann fold.
 
  
 0.465
ispH
Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
  
  
 0.452
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
     0.437
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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