Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH44290.1InterPro IPR001806; KEGG: sfu:Sfum_0318 gliding motility protein (MglA); SPTR: Gliding motility protein (MglA); IMG reference gene:2505283697; PFAM: Ras family. (214 aa)    
Predicted Functional Partners:
AEH44289.1
Roadblock/LC7 family protein; InterPro IPR004942; KEGG: sfu:Sfum_0317 roadblock/LC7 family protein; PFAM: Roadblock/LC7 family protein; SPTR: Roadblock/LC7 family protein; IMG reference gene:2505283696; PFAM: Roadblock/LC7 domain.
 
 
 0.998
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
   
 0.870
AEH44292.1
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterProIPR001440:IPR007831:IPR001482:IPR019734:IPR 013026:IPR003593; KEGG: sat:SYN_01404 general secretion pathway protein E; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SMART: AAA ATPase; Tetratricopeptide repeat; SPTR: General secretion pathway protein E; IMG reference gene:2505283699; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain.
  
  
 0.785
AEH44291.1
KEGG: pkn:PKH_130600 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283698.
       0.778
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
   
 
 0.755
AEH44288.1
COGs: COG1639 signal transduction protein; InterPro IPR006675:IPR013976; KEGG: dar:Daro_1978 HDIG; PFAM: Metal-dependent hydrolase HDOD; SPTR: HDIG; TIGRFAM: metal dependent phophohydrolase; IMG reference gene:2505283695; PFAM: HDOD domain; TIGRFAM: uncharacterized domain HDIG.
       0.540
AEH44397.1
COGs: COG4972 Tfp pilus assembly protein ATPase PilM; KEGG: dol:Dole_0333 type IV pilus assembly protein PilM; SPTR: Type IV pilus assembly protein PilM; IMG reference gene:2505283809; PFAM: Competence protein A; TIGRFAM: type IV pilus assembly protein PilM.
  
   
 0.532
AEH44293.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR013767:IPR003661:IPR003594:IPR 004358:IPR005467:IPR000700; KEGG: tye:THEYE_A0125 sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensor histidine kinase; TIGRFAM: PAS sensor protein; IMG reference gene:2505283700; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like [...]
       0.505
AEH44294.1
Two component, sigma54 specific, transcriptional regulator, Fis family; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR001789:IPR002078:IPR002197:IPR020441:IPR 003593; KEGG: sfu:Sfum_2764 two component, sigma54 specific, fis family transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; response regulator receiver; helix-turn-helix Fis-type; SMART: response regulator receiver; AAA ATPase; SPTR: Two component, sigma54 specific, transcriptional regulator, Fis family; IMG reference gene:250 [...]
       0.505
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 0.403
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.