STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AEH44382.1Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR005244:IPR006638; KEGG: pth:PTH_0983 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Biotin synthase and related enzymes; manually curated; IMG reference gene:2505283789; PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE. (331 aa)    
Predicted Functional Partners:
AEH44381.1
Small GTP-binding protein; COGs: COG1160 GTPase; InterPro IPR005225:IPR002917:IPR001806:IPR003577; KEGG: pca:Pcar_1629 GTPases; PFAM: GTP-binding protein HSR1-related; SMART: Ras small GTPase, Ras type; SPTR: Predicted GTPases; TIGRFAM: small GTP-binding protein; IMG reference gene:2505283788; PFAM: GTPase of unknown function; TIGRFAM: hydrogenase maturation GTPase HydF; small GTP-binding protein domain.
   
 0.994
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.980
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
  0.926
AEH44822.1
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143:IPR003142:IPR004408; KEGG: afl:Aflv_1125 biotin operon repressor containing HTH and biotin-(acetyl-CoA carboxylase) ligase domains; PFAM: biotin/lipoate A/B protein ligase; biotin protein ligase domain protein; SPTR: Biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; IMG reference gene:2505284255; PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
  
 
 0.910
AEH45764.1
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143:IPR004408; KEGG: dak:DaAHT2_0465 biotin/acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; SPTR: Biotin/acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; IMG reference gene:2505285240; PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
  
 
 0.910
AEH44377.1
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR013352:IPR004108:IPR003149:IPR017896:IPR 017900; KEGG: hor:Hore_06330 NADH dehydrogenase (ubiquinone) 75 kDa subunit; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; PRIAM: Ferredoxin hydrogenase; SPTR: NADH dehydrogenase (Ubiquinone) 75 kDa subunit; TIGRFAM: hydrogenase, Fe-only; IMG reference gene:2505283784; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Iron hydrogenase small subunit; TIGRFAM: hydrogenase, Fe-only.
 
  
 0.879
AEH44380.1
COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR004108:IPR017896:IPR017900; KEGG: tye:THEYE_A1726 hydrogenase; PFAM: hydrogenase large subunit domain protein; PRIAM: Ferredoxin hydrogenase; SPTR: Hydrogenase; IMG reference gene:2505283787; PFAM: Iron only hydrogenase large subunit, C-terminal domain; 4Fe-4S binding domain; TIGRFAM: hydrogenase, Fe-only.
 
  
 0.850
AEH44376.1
KEGG: ate:Athe_0168 putative transcriptional regulator, CopG family; SPTR: Putative uncharacterized protein; IMG reference gene:2505283783; TIGRFAM: putative iron-only hydrogenase system regulator.
 
    0.807
AEH44379.1
InterPro IPR003149; KEGG: she:Shewmr4_3251 iron hydrogenase, small subunit; PFAM: iron hydrogenase small subunit; SPTR: Iron hydrogenase, small subunit; IMG reference gene:2505283786; PFAM: Iron hydrogenase small subunit.
 
   
 0.778
AEH45232.1
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR006311:IPR013352:IPR004108:IPR003149:IPR 006058:IPR017900:IPR017909:IPR017896; KEGG: pth:PTH_0668 iron only hydrogenase large subunit; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; PRIAM: Ferredoxin hydrogenase; SPTR: Iron only hydrogenase large subunit, C-terminal domain; TIGRFAM: hydrogenase, Fe-only; IMG reference gene:2505284680; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Iron hydrogenase small subunit; TIGRFAM: hydrogenase, Fe-only.
 
  
 0.761
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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