Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH44399.1COGs: COG0681 Signal peptidase I; InterProIPR000223:IPR019759:IPR019756:IPR019757:IPR 019758; KEGG: tye:THEYE_A0098 signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; PRIAM: Signal peptidase I; SPTR: Signal peptidase I; TIGRFAM: signal peptidase I; IMG reference gene:2505283811; PFAM: Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type. (212 aa)    
Predicted Functional Partners:
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.979
AEH45268.1
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sat:SYN_00945 RNA polymerase sigma-54 factor; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: RNA polymerase sigma-54 factor; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; IMG reference gene:2505284717; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
  
  
 0.867
AEH45157.1
COGs: COG0704 Phosphate uptake regulator; InterPro IPR008170:IPR002727:IPR018445; KEGG: dal:Dalk_1431 phosphate uptake regulator, PhoU; PFAM: PhoU family protein; Putitive phosphate transport regulator; SPTR: Phosphate uptake regulator, PhoU; TIGRFAM: phosphate transport system regulatory protein PhoU; IMG reference gene:2505284604; PFAM: Protein of unknown function DUF47; PhoU domain; TIGRFAM: TIGR00153 family protein; phosphate transport system regulatory protein PhoU.
  
    0.834
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
  
 0.828
secF
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.826
AEH45662.1
Hypothetical protein; InterPro IPR019734:IPR013026; KEGG: dak:DaAHT2_1194 tetratricopeptide TPR_4; SPTR: Tetratricopeptide TPR_4; IMG reference gene:2505285133.
  
  
 0.826
AEH45020.1
Outer membrane assembly lipoprotein YfiO; COGs: COG4105 DNA uptake lipoprotein; InterPro IPR017689:IPR013026; KEGG: dal:Dalk_2404 outer membrane assembly lipoprotein YfiO; SPTR: Outer membrane assembly lipoprotein YfiO; TIGRFAM: outer membrane assembly lipoprotein YfiO; IMG reference gene:2505284462; TIGRFAM: outer membrane assembly lipoprotein YfiO.
 
  
 0.801
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
  
 0.789
AEH44766.1
NAD-dependent epimerase/dehydratase; COGs: COG1090 nucleoside-diphosphate sugar epimerase; InterPro IPR001509:IPR013549:IPR010099; KEGG: dak:DaAHT2_0933 domain of unknown function DUF1731; PFAM: NAD-dependent epimerase/dehydratase; domain of unknown function DUF1731; SPTR: Putative uncharacterized protein; IMG reference gene:2505284193; PFAM: NAD dependent epimerase/dehydratase family; Domain of unknown function (DUF1731); TIGRFAM: TIGR01777 family protein.
   
    0.780
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.757
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.