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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (551 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.974
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 
 0.972
ilvD
COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581:IPR004404:IPR020558; KEGG: sat:SYN_01708 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; IMG reference gene:2505283287; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.956
AEH45235.1
COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR005786:IPR001544:IPR018300; KEGG: dak:DaAHT2_2175 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain-amino-acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; IMG reference gene:2505284683; PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.954
AEH44845.1
Carbamoyl-phosphate synthase L chain ATP-binding protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005479:IPR005481:IPR005482:IPR011761:IPR 011764; KEGG: rca:Rcas_2955 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; SPTR: Carbamoyl-phosphate synthase L chain ATP-binding; IMG reference gene:2505284282; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Car [...]
  
 
 0.939
AEH45842.1
Pyruvate carboxylase; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR005479:IPR005481:IPR005482:IPR011761:IPR 011764; KEGG: dak:DaAHT2_0460 pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; PRIAM: Pyruvate carboxylase; SPTR: Pyruvate carboxylase; IMG reference gene:2505285324; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain.
  
 
 0.939
AEH44919.1
Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034:IPR000891; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; IMG reference gene:2505284358; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.924
AEH44186.1
2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR013709:IPR005675:IPR002034; KEGG: sfu:Sfum_2174 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; IMG reference gene:2505283591; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthas [...]
  
  
 
0.923
AEH45773.1
Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: tye:THEYE_A1275 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; IMG reference gene:2505285253; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-te [...]
 
 
 0.923
AEH45774.1
COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: dak:DaAHT2_0726 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; IMG reference gene:2505285254; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.
 
 
 0.917
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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